The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Alexandra Johnson Valiente, Kin Seng Liem, Kathleen B. Schwarz, Philip Rosenthal, Karen F. Murray, Douglas Mogul, Jeffery Teckman, Norberto Rodriguez-Baez, Sarah Jane Schwarzenberg, Jordan J. Feld, David K. Wong, Lia L. Lewis-Ximenez, Georg Lauer, Bettina E. Hansen, Simon C. Ling, Harry L.A. Janssen, Adam J. Gehring

Research output: Contribution to journalArticlepeer-review

Abstract

Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

Original languageEnglish (US)
Pages (from-to)470-475
Number of pages6
JournalThe Journal of infectious diseases
Volume225
Issue number3
DOIs
StatePublished - Feb 1 2022
Externally publishedYes

Keywords

  • HBV
  • biomarker
  • chemokines
  • cytokines
  • flare
  • hepatitis B
  • immune response
  • inflammation
  • plasma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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