The inflammatory response to cardiopulmonary bypass - Should it be treated?

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Proinflammatory cytokines, including tumor necrosis factor (TNF) α and the interleukins, are important in the metabolic response to injury or infection. Although the importance of cytokine release during cardiopulmonary bypass (CPB) is not fully appreciated, increasing numbers of publications present evidence that cytokine release during CPB is detrimental. In addition, endogenous inhibitors of cytokine function, including TNF-soluble receptor and interleukin 1 receptor antagonist, are released in response to elevated proinflammatory cytokine levels during and after CPB. The involvement of these endogenous inhibitors in the pathophysiology of proinflammatory cytokine-induced solid organ injury after CPB remains to be defined.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalSeminars in Cardiothoracic and Vascular Anesthesia
Volume5
Issue number3
DOIs
StatePublished - Jan 1 2001

Fingerprint

Cardiopulmonary Bypass
Cytokines
Interleukin-1 Receptors
Tumor Necrosis Factor Receptors
Interleukins
Wounds and Injuries
Tumor Necrosis Factor-alpha
Infection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

Cite this

The inflammatory response to cardiopulmonary bypass - Should it be treated? / Hill, G. E.

In: Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 5, No. 3, 01.01.2001, p. 229-235.

Research output: Contribution to journalArticle

@article{042c2429176d4f06be1d97508dd99210,
title = "The inflammatory response to cardiopulmonary bypass - Should it be treated?",
abstract = "Proinflammatory cytokines, including tumor necrosis factor (TNF) α and the interleukins, are important in the metabolic response to injury or infection. Although the importance of cytokine release during cardiopulmonary bypass (CPB) is not fully appreciated, increasing numbers of publications present evidence that cytokine release during CPB is detrimental. In addition, endogenous inhibitors of cytokine function, including TNF-soluble receptor and interleukin 1 receptor antagonist, are released in response to elevated proinflammatory cytokine levels during and after CPB. The involvement of these endogenous inhibitors in the pathophysiology of proinflammatory cytokine-induced solid organ injury after CPB remains to be defined.",
author = "Hill, {G. E.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1053/scva.2001.26128",
language = "English (US)",
volume = "5",
pages = "229--235",
journal = "Seminars in Cardiothoracic and Vascular Anesthesia",
issn = "1089-2532",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - The inflammatory response to cardiopulmonary bypass - Should it be treated?

AU - Hill, G. E.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Proinflammatory cytokines, including tumor necrosis factor (TNF) α and the interleukins, are important in the metabolic response to injury or infection. Although the importance of cytokine release during cardiopulmonary bypass (CPB) is not fully appreciated, increasing numbers of publications present evidence that cytokine release during CPB is detrimental. In addition, endogenous inhibitors of cytokine function, including TNF-soluble receptor and interleukin 1 receptor antagonist, are released in response to elevated proinflammatory cytokine levels during and after CPB. The involvement of these endogenous inhibitors in the pathophysiology of proinflammatory cytokine-induced solid organ injury after CPB remains to be defined.

AB - Proinflammatory cytokines, including tumor necrosis factor (TNF) α and the interleukins, are important in the metabolic response to injury or infection. Although the importance of cytokine release during cardiopulmonary bypass (CPB) is not fully appreciated, increasing numbers of publications present evidence that cytokine release during CPB is detrimental. In addition, endogenous inhibitors of cytokine function, including TNF-soluble receptor and interleukin 1 receptor antagonist, are released in response to elevated proinflammatory cytokine levels during and after CPB. The involvement of these endogenous inhibitors in the pathophysiology of proinflammatory cytokine-induced solid organ injury after CPB remains to be defined.

UR - http://www.scopus.com/inward/record.url?scp=0034837319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034837319&partnerID=8YFLogxK

U2 - 10.1053/scva.2001.26128

DO - 10.1053/scva.2001.26128

M3 - Article

AN - SCOPUS:0034837319

VL - 5

SP - 229

EP - 235

JO - Seminars in Cardiothoracic and Vascular Anesthesia

JF - Seminars in Cardiothoracic and Vascular Anesthesia

SN - 1089-2532

IS - 3

ER -