The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions

Clay Cockerell, Jaime Tschen, Steven D. Billings, Brent Evans, Krystal Brown, Colleen Rock, Loren E. Clarke

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Aim: The effect of a gene-expression-based test on treatment of melanocytic neoplasms by dermatologists was evaluated. Patients & methods: Pathologists submitted diagnostically challenging melanocytic neoplasms to a clinical laboratory for testing accompanied by pretest surveys documenting the intended treatment recommendations. The actual treatment rendered by dermatologists was then documented after testing. Changes between the pretest recommendations and actual treatment were analyzed. Results: In 71.4% (55/77) of cases, there was a change from pretest recommendations to actual treatment. The majority of changes were consistent with the test result. There was an 80.5% (33/41) reduction in the number of biopsy site re-excisions performed for cases with a benign test result. Conclusion: The actual treatment of diagnostically challenging melanocytic neoplasms is influenced by the test.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalPersonalized Medicine
Volume14
Issue number2
DOIs
StatePublished - Mar 1 2017

Keywords

  • clinical utility
  • gene-expression signature
  • melanocytic nevi
  • melanoma
  • molecular diagnostic techniques
  • RT-PCR

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Medicine
  • Pharmacology

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    Cockerell, C., Tschen, J., Billings, S. D., Evans, B., Brown, K., Rock, C., & Clarke, L. E. (2017). The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions. Personalized Medicine, 14(2), 123-130. https://doi.org/10.2217/pme-2016-0097