The influence of age on the response of major depression to electroconvulsive therapy: A C.O.R.E. report

M. Kevin O'Connor, Rebecca Knapp, Mustafa Husain, Teresa A. Rummans, Georgios Petrides, Glenn Smith, Martina Mueller, Karen Snyder, Hilary Bernstein, A. John Rush, Max Fink, Charles Kellner

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

As part of a C.O.R.E., multi-site longitudinal study comparing continuation electro-convulsive therapy (ECT) vs. continuation pharmacotherapy, the authors determined the response of 253 patients with major depression to acute-phase, bilateral ECT by use of the 24-item Hamilton Rating Scale for Depression. Remission rates for three age-groups, ≥65 years; 46-64 years; and ≤45 years, were 90 percent, 89.8 percent, and 70 percent, respectively. Age, as a continuous variable, positively influenced response to treatment. Bilateral, dose-titrated ECT is a highly effective acute treatment for major depression, and older age confers a greater likelihood of achieving remission.

Original languageEnglish (US)
Pages (from-to)382-390
Number of pages9
JournalAmerican Journal of Geriatric Psychiatry
Volume9
Issue number4
DOIs
StatePublished - 2001

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Convulsive Therapy
Electroconvulsive Therapy
Depression
Longitudinal Studies
Age Groups
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

The influence of age on the response of major depression to electroconvulsive therapy : A C.O.R.E. report. / O'Connor, M. Kevin; Knapp, Rebecca; Husain, Mustafa; Rummans, Teresa A.; Petrides, Georgios; Smith, Glenn; Mueller, Martina; Snyder, Karen; Bernstein, Hilary; Rush, A. John; Fink, Max; Kellner, Charles.

In: American Journal of Geriatric Psychiatry, Vol. 9, No. 4, 2001, p. 382-390.

Research output: Contribution to journalArticle

O'Connor, MK, Knapp, R, Husain, M, Rummans, TA, Petrides, G, Smith, G, Mueller, M, Snyder, K, Bernstein, H, Rush, AJ, Fink, M & Kellner, C 2001, 'The influence of age on the response of major depression to electroconvulsive therapy: A C.O.R.E. report', American Journal of Geriatric Psychiatry, vol. 9, no. 4, pp. 382-390. https://doi.org/10.1097/00019442-200111000-00006
O'Connor, M. Kevin ; Knapp, Rebecca ; Husain, Mustafa ; Rummans, Teresa A. ; Petrides, Georgios ; Smith, Glenn ; Mueller, Martina ; Snyder, Karen ; Bernstein, Hilary ; Rush, A. John ; Fink, Max ; Kellner, Charles. / The influence of age on the response of major depression to electroconvulsive therapy : A C.O.R.E. report. In: American Journal of Geriatric Psychiatry. 2001 ; Vol. 9, No. 4. pp. 382-390.
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