The influence of age on the response of major depression to electroconvulsive therapy: A C.O.R.E. report

M. Kevin O'Connor, Rebecca Knapp, Mustafa Husain, Teresa A. Rummans, Georgios Petrides, Glenn Smith, Martina Mueller, Karen Snyder, Hilary Bernstein, A. John Rush, Max Fink, Charles Kellner

Research output: Contribution to journalArticle

194 Scopus citations

Abstract

As part of a C.O.R.E., multi-site longitudinal study comparing continuation electro-convulsive therapy (ECT) vs. continuation pharmacotherapy, the authors determined the response of 253 patients with major depression to acute-phase, bilateral ECT by use of the 24-item Hamilton Rating Scale for Depression. Remission rates for three age-groups, ≥65 years; 46-64 years; and ≤45 years, were 90 percent, 89.8 percent, and 70 percent, respectively. Age, as a continuous variable, positively influenced response to treatment. Bilateral, dose-titrated ECT is a highly effective acute treatment for major depression, and older age confers a greater likelihood of achieving remission.

Original languageEnglish (US)
Pages (from-to)382-390
Number of pages9
JournalAmerican Journal of Geriatric Psychiatry
Volume9
Issue number4
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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    O'Connor, M. K., Knapp, R., Husain, M., Rummans, T. A., Petrides, G., Smith, G., Mueller, M., Snyder, K., Bernstein, H., Rush, A. J., Fink, M., & Kellner, C. (2001). The influence of age on the response of major depression to electroconvulsive therapy: A C.O.R.E. report. American Journal of Geriatric Psychiatry, 9(4), 382-390. https://doi.org/10.1097/00019442-200111000-00006