The influence of cold insoluble globulin on platelet morphological response to substrata

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Abstract

Light microscopic studies have been carried out on the attachment and morphological responses of washed human platelets in serum-free medium to fibrinogen-coated, collagen-coated and uncoated tissue culture plastic substrata. Platelets were observed to attach to the substratum, extend filipodia and undergo spreading. Subsequently, lysis of platelets occurred. On uncoated tissue culture plastic substrata, the addition of cold insoluble globulin to the incubations had no effect on the above morphological changes. On the other hand, on the protein coated substrata, there was very little platelet spreading or lysis without the addition of cold insoluble globulin.

Original languageEnglish (US)
Pages (from-to)585-592
Number of pages8
JournalCell Biology International Reports
Volume3
Issue number7
DOIs
StatePublished - 1979

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Fibronectins
Blood Platelets
Plastics
Serum-Free Culture Media
Fibrinogen
Collagen
Light
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

The influence of cold insoluble globulin on platelet morphological response to substrata. / Grinnell, Frederick; Feld, Marian; Snell, William.

In: Cell Biology International Reports, Vol. 3, No. 7, 1979, p. 585-592.

Research output: Contribution to journalArticle

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