TY - JOUR
T1 - The influence of cold insoluble globulin on platelet morphological response to substrata
AU - Grinnell, Frederick
AU - Feld, Marian
AU - Snell, William
N1 - Funding Information:
ACKNOWLEDGEMENTWS.e are indebted to Dr. James George and Dr. Marjorie Zucker for their critical reading and assistance in the preparation of this paper. This research was supported by a grant from The American Heart Association, Texas Heart Affiliate.
PY - 1979/10
Y1 - 1979/10
N2 - Light microscopic studies have been carried out on the attachment and morphological responses of washed human platelets in serum-free medium to fibrinogen-coated, collagen-coated and uncoated tissue culture plastic substrata. Platelets were observed to attach to the substratum, extend filipodia and undergo spreading. Subsequently, lysis of platelets occurred. On uncoated tissue culture plastic substrata, the addition of cold insoluble globulin to the incubations had no effect on the above morphological changes. On the other hand, on the protein coated substrata, there was very little platelet spreading or lysis without the addition of cold insoluble globulin.
AB - Light microscopic studies have been carried out on the attachment and morphological responses of washed human platelets in serum-free medium to fibrinogen-coated, collagen-coated and uncoated tissue culture plastic substrata. Platelets were observed to attach to the substratum, extend filipodia and undergo spreading. Subsequently, lysis of platelets occurred. On uncoated tissue culture plastic substrata, the addition of cold insoluble globulin to the incubations had no effect on the above morphological changes. On the other hand, on the protein coated substrata, there was very little platelet spreading or lysis without the addition of cold insoluble globulin.
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U2 - 10.1016/0309-1651(79)90056-0
DO - 10.1016/0309-1651(79)90056-0
M3 - Article
C2 - 535037
AN - SCOPUS:0018702475
SN - 0309-1651
VL - 3
SP - 585
EP - 592
JO - Cell Biology International Reports
JF - Cell Biology International Reports
IS - 7
ER -