The influence of combined intra aortic balloon counterpulsation and hyperosmotic mannitol on regional myocardial blood flow in ischemic myocardium in the dog

J. T. Watson, David E Fixler, M. R. Platt, B. B. Nall, G. K. Jett, J. T. Willerson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The authors investigated the combined effectiveness of intraaortic balloon counterpulsation and hyperosmotic mannitol (25%) on regional myocardial blood flow during acute coronary insufficiency. Cardiac output and paced heart rate were held constant in chloralose anesthetized dogs during right heart bypass. Acute coronary insufficiency was produced by ligation of the proximal left anterior descending coronary artery (LAD). Regional myocardial blood flow was measured using radioactive microspheres. Left ventricular end diastolic pressure, mean aortic pressure, maximum left ventricular dp/dt, and hematocrit were unchanged by combined mannitol infusion and balloon pumping. Studies of combined treatment with balloon pumping and mannitol immediately after the second of two 13 minute consecutive reversible ligations of the LAD demonstrated that (1) collateral coronary blood flow increased 46% (P<0.02) in ischemic myocardium compared with mannitol infusion alone during the first LAD ligation, and (2) collateral coronary blood flow increased 27% (P<0.05) in ischemic myocardium compared with balloon pumping along during the first LAD ligation. Studies in which combined treatment was delayed until 20 minutes after LAD ligation demonstrated that collateral coronary blood flow was elevated by 33% (P < 0.05) in ischemic myocardium compared to control studies in which balloon pumping alone had no effect. The results suggest that the increase in collateral coronary blood flow was in part a result of an increased transmural pressure gradient produced by balloon diastolic augmentation and the ability of mannitol to reduce coronary vascular resistance in ischemic myocardium.

Original languageEnglish (US)
Pages (from-to)506-513
Number of pages8
JournalCirculation Research
Volume38
Issue number6
StatePublished - 1976

Fingerprint

Counterpulsation
Regional Blood Flow
Mannitol
Ligation
Myocardium
Dogs
Right Heart Bypass
Chloralose
Microspheres
Hematocrit
Cardiac Output
Vascular Resistance
Coronary Vessels
Arterial Pressure
Heart Rate
Blood Pressure
Pressure

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

The influence of combined intra aortic balloon counterpulsation and hyperosmotic mannitol on regional myocardial blood flow in ischemic myocardium in the dog. / Watson, J. T.; Fixler, David E; Platt, M. R.; Nall, B. B.; Jett, G. K.; Willerson, J. T.

In: Circulation Research, Vol. 38, No. 6, 1976, p. 506-513.

Research output: Contribution to journalArticle

@article{ecf8989eb07e4a03a9b10174ea97887f,
title = "The influence of combined intra aortic balloon counterpulsation and hyperosmotic mannitol on regional myocardial blood flow in ischemic myocardium in the dog",
abstract = "The authors investigated the combined effectiveness of intraaortic balloon counterpulsation and hyperosmotic mannitol (25{\%}) on regional myocardial blood flow during acute coronary insufficiency. Cardiac output and paced heart rate were held constant in chloralose anesthetized dogs during right heart bypass. Acute coronary insufficiency was produced by ligation of the proximal left anterior descending coronary artery (LAD). Regional myocardial blood flow was measured using radioactive microspheres. Left ventricular end diastolic pressure, mean aortic pressure, maximum left ventricular dp/dt, and hematocrit were unchanged by combined mannitol infusion and balloon pumping. Studies of combined treatment with balloon pumping and mannitol immediately after the second of two 13 minute consecutive reversible ligations of the LAD demonstrated that (1) collateral coronary blood flow increased 46{\%} (P<0.02) in ischemic myocardium compared with mannitol infusion alone during the first LAD ligation, and (2) collateral coronary blood flow increased 27{\%} (P<0.05) in ischemic myocardium compared with balloon pumping along during the first LAD ligation. Studies in which combined treatment was delayed until 20 minutes after LAD ligation demonstrated that collateral coronary blood flow was elevated by 33{\%} (P < 0.05) in ischemic myocardium compared to control studies in which balloon pumping alone had no effect. The results suggest that the increase in collateral coronary blood flow was in part a result of an increased transmural pressure gradient produced by balloon diastolic augmentation and the ability of mannitol to reduce coronary vascular resistance in ischemic myocardium.",
author = "Watson, {J. T.} and Fixler, {David E} and Platt, {M. R.} and Nall, {B. B.} and Jett, {G. K.} and Willerson, {J. T.}",
year = "1976",
language = "English (US)",
volume = "38",
pages = "506--513",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - The influence of combined intra aortic balloon counterpulsation and hyperosmotic mannitol on regional myocardial blood flow in ischemic myocardium in the dog

AU - Watson, J. T.

AU - Fixler, David E

AU - Platt, M. R.

AU - Nall, B. B.

AU - Jett, G. K.

AU - Willerson, J. T.

PY - 1976

Y1 - 1976

N2 - The authors investigated the combined effectiveness of intraaortic balloon counterpulsation and hyperosmotic mannitol (25%) on regional myocardial blood flow during acute coronary insufficiency. Cardiac output and paced heart rate were held constant in chloralose anesthetized dogs during right heart bypass. Acute coronary insufficiency was produced by ligation of the proximal left anterior descending coronary artery (LAD). Regional myocardial blood flow was measured using radioactive microspheres. Left ventricular end diastolic pressure, mean aortic pressure, maximum left ventricular dp/dt, and hematocrit were unchanged by combined mannitol infusion and balloon pumping. Studies of combined treatment with balloon pumping and mannitol immediately after the second of two 13 minute consecutive reversible ligations of the LAD demonstrated that (1) collateral coronary blood flow increased 46% (P<0.02) in ischemic myocardium compared with mannitol infusion alone during the first LAD ligation, and (2) collateral coronary blood flow increased 27% (P<0.05) in ischemic myocardium compared with balloon pumping along during the first LAD ligation. Studies in which combined treatment was delayed until 20 minutes after LAD ligation demonstrated that collateral coronary blood flow was elevated by 33% (P < 0.05) in ischemic myocardium compared to control studies in which balloon pumping alone had no effect. The results suggest that the increase in collateral coronary blood flow was in part a result of an increased transmural pressure gradient produced by balloon diastolic augmentation and the ability of mannitol to reduce coronary vascular resistance in ischemic myocardium.

AB - The authors investigated the combined effectiveness of intraaortic balloon counterpulsation and hyperosmotic mannitol (25%) on regional myocardial blood flow during acute coronary insufficiency. Cardiac output and paced heart rate were held constant in chloralose anesthetized dogs during right heart bypass. Acute coronary insufficiency was produced by ligation of the proximal left anterior descending coronary artery (LAD). Regional myocardial blood flow was measured using radioactive microspheres. Left ventricular end diastolic pressure, mean aortic pressure, maximum left ventricular dp/dt, and hematocrit were unchanged by combined mannitol infusion and balloon pumping. Studies of combined treatment with balloon pumping and mannitol immediately after the second of two 13 minute consecutive reversible ligations of the LAD demonstrated that (1) collateral coronary blood flow increased 46% (P<0.02) in ischemic myocardium compared with mannitol infusion alone during the first LAD ligation, and (2) collateral coronary blood flow increased 27% (P<0.05) in ischemic myocardium compared with balloon pumping along during the first LAD ligation. Studies in which combined treatment was delayed until 20 minutes after LAD ligation demonstrated that collateral coronary blood flow was elevated by 33% (P < 0.05) in ischemic myocardium compared to control studies in which balloon pumping alone had no effect. The results suggest that the increase in collateral coronary blood flow was in part a result of an increased transmural pressure gradient produced by balloon diastolic augmentation and the ability of mannitol to reduce coronary vascular resistance in ischemic myocardium.

UR - http://www.scopus.com/inward/record.url?scp=0017184299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017184299&partnerID=8YFLogxK

M3 - Article

C2 - 1269100

AN - SCOPUS:0017184299

VL - 38

SP - 506

EP - 513

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 6

ER -