The influence of Helicobacter pylori on the ethnic distribution of esophageal eosinophilia

Amnon Sonnenberg, Evan S. Dellon, Kevin O. Turner, Robert M. Genta

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Environmental factors associated with ethnicity may contribute to the occurrence of eosinophilic esophagitis. Our study aimed to investigate the influence of Helicobacter pylori on the ethnic variation of esophageal eosinophilia in a large national sample of patients undergoing esophago-gastro-duodenoscopy. Methods: The Miraca Life Sciences Database is an electronic repository of histopathologic patient records. A case-control study evaluated the influence of ethnicity on the occurrence of esophageal eosinophilia and how age, gender, and histologic diagnosis of H. pylori modify this relationship. Results: The total study population comprised 596 479 subjects, of whom 25 969 harbored a diagnosis of esophageal eosinophilia. Young age, male sex, and H. pylori infection in declining order exerted the strongest influence on the occurrence of esophageal eosinophilia. In comparison with the population comprising of Caucasians and African-Americans, esophageal eosinophilia was less common among patients of African (OR=0.10, 95% CI=0.01-0.46), Middle Eastern (0.22, 0.15-0.31), East Asian (0.32, 0.26-0.38), Indian (0.28, 0.21-0.37), Hispanic (0.40, 0.37-0.43), or Jewish descent (0.58, 0.51-0.66), but more common among patients of Northern European descent (1.25, 1.07-1.45). With the exception of Northern Europeans, all ethnic subgroups were characterized by a higher prevalence of H. pylori than the comparison group. A low prevalence of H. pylori was significantly associated with a high prevalence of esophageal eosinophilia (R2=0.90, P<.001). Conclusion: Esophageal eosinophilia prevalence markedly varies by patient ethnicity. As there is a strong inverse correlation between H. pylori and esophageal eosinophilia, H. pylori infection may be in part responsible for the observed ethnic distribution of esophageal eosinophilia.

Original languageEnglish (US)
Article numbere12370
JournalHelicobacter
Volume22
Issue number3
DOIs
StatePublished - Jun 1 2017

Fingerprint

Eosinophilia
Helicobacter pylori
Pylorus
Duodenoscopy
Eosinophilic Esophagitis
Biological Science Disciplines
Infection
Hispanic Americans
African Americans
Population
Case-Control Studies
Databases

Keywords

  • environmental risk factors
  • eosinophilic esophagitis
  • epidemiology
  • ethnicity
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases

Cite this

Sonnenberg, A., Dellon, E. S., Turner, K. O., & Genta, R. M. (2017). The influence of Helicobacter pylori on the ethnic distribution of esophageal eosinophilia. Helicobacter, 22(3), [e12370]. https://doi.org/10.1111/hel.12370

The influence of Helicobacter pylori on the ethnic distribution of esophageal eosinophilia. / Sonnenberg, Amnon; Dellon, Evan S.; Turner, Kevin O.; Genta, Robert M.

In: Helicobacter, Vol. 22, No. 3, e12370, 01.06.2017.

Research output: Contribution to journalArticle

Sonnenberg, Amnon ; Dellon, Evan S. ; Turner, Kevin O. ; Genta, Robert M. / The influence of Helicobacter pylori on the ethnic distribution of esophageal eosinophilia. In: Helicobacter. 2017 ; Vol. 22, No. 3.
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AB - Background: Environmental factors associated with ethnicity may contribute to the occurrence of eosinophilic esophagitis. Our study aimed to investigate the influence of Helicobacter pylori on the ethnic variation of esophageal eosinophilia in a large national sample of patients undergoing esophago-gastro-duodenoscopy. Methods: The Miraca Life Sciences Database is an electronic repository of histopathologic patient records. A case-control study evaluated the influence of ethnicity on the occurrence of esophageal eosinophilia and how age, gender, and histologic diagnosis of H. pylori modify this relationship. Results: The total study population comprised 596 479 subjects, of whom 25 969 harbored a diagnosis of esophageal eosinophilia. Young age, male sex, and H. pylori infection in declining order exerted the strongest influence on the occurrence of esophageal eosinophilia. In comparison with the population comprising of Caucasians and African-Americans, esophageal eosinophilia was less common among patients of African (OR=0.10, 95% CI=0.01-0.46), Middle Eastern (0.22, 0.15-0.31), East Asian (0.32, 0.26-0.38), Indian (0.28, 0.21-0.37), Hispanic (0.40, 0.37-0.43), or Jewish descent (0.58, 0.51-0.66), but more common among patients of Northern European descent (1.25, 1.07-1.45). With the exception of Northern Europeans, all ethnic subgroups were characterized by a higher prevalence of H. pylori than the comparison group. A low prevalence of H. pylori was significantly associated with a high prevalence of esophageal eosinophilia (R2=0.90, P<.001). Conclusion: Esophageal eosinophilia prevalence markedly varies by patient ethnicity. As there is a strong inverse correlation between H. pylori and esophageal eosinophilia, H. pylori infection may be in part responsible for the observed ethnic distribution of esophageal eosinophilia.

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