The influence of lipids on voltage-gated ion channels

Qiu Xing Jiang, Tamir Gonen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Voltage-gated ion channels are responsible for transmitting electrochemical signals in both excitable and non-excitable cells. Structural studies of voltage-gated potassium and sodium channels by X-ray crystallography have revealed atomic details on their voltage-sensor domains (VSDs) and pore domains, and were put in context of disparate mechanistic views on the voltage-driven conformational changes in these proteins. Functional investigation of voltage-gated channels in membranes, however, showcased a mechanism of lipid-dependent gating for voltage-gated channels, suggesting that the lipids play an indispensible and critical role in the proper gating of many of these channels. Structure determination of membrane-embedded voltage-gated ion channels appears to be the next frontier in fully addressing the mechanism by which the VSDs control channel opening. Currently electron crystallography is the only structural biology method in which a membrane protein of interest is crystallized within a complete lipid-bilayer mimicking the native environment of a biological membrane. At a sufficiently high resolution, an electron crystallographic structure could reveal lipids, the channel and their mutual interactions at the atomic level. Electron crystallography is therefore a promising avenue toward understanding how lipids modulate channel activation through close association with the VSDs.

Original languageEnglish (US)
Pages (from-to)529-536
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume22
Issue number4
DOIs
StatePublished - Aug 2012

Fingerprint

Ion Channels
Lipids
Crystallography
Electrons
Voltage-Gated Sodium Channels
Voltage-Gated Potassium Channels
Membranes
X Ray Crystallography
Lipid Bilayers
Membrane Proteins
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

The influence of lipids on voltage-gated ion channels. / Jiang, Qiu Xing; Gonen, Tamir.

In: Current Opinion in Structural Biology, Vol. 22, No. 4, 08.2012, p. 529-536.

Research output: Contribution to journalArticle

Jiang, Qiu Xing ; Gonen, Tamir. / The influence of lipids on voltage-gated ion channels. In: Current Opinion in Structural Biology. 2012 ; Vol. 22, No. 4. pp. 529-536.
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