The influence of orexin on sleep and wakefulness

Christopher M. Sinton, Jon T. Willie

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

An exciting recent development in sleep research was the discovery of the importance for vigilance state control and narcolepsy-cataplexy of neurons containing orexin (also known as hypocretin) neuropeptides. Narcolepsycataplexy is a chronic, debilitating sleep disorder that is characterized by excessive daytime sleepiness, manifested as attacks of daytime somnolence at inappropriate times. 1-3 Narcoleptics also show symptoms that are considered indicative of abnormal REM (Rapid Eye Movement) sleep expression. These latter symptoms include cataplexy, hypnogogic hallucinations, sleep-onset REM periods, and sleep paralysis.

Original languageEnglish (US)
Title of host publicationNeuroendocrine Correlates of Sleep/Wakefulness
PublisherSpringer US
Pages221-240
Number of pages20
ISBN (Electronic)9780387236926
ISBN (Print)0387236414, 9780387236414
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience

Fingerprint

Dive into the research topics of 'The influence of orexin on sleep and wakefulness'. Together they form a unique fingerprint.

Cite this