The influence of orexin on sleep and wakefulness

Christopher M. Sinton, Jon T. Willie

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

An exciting recent development in sleep research was the discovery of the importance for vigilance state control and narcolepsy-cataplexy of neurons containing orexin (also known as hypocretin) neuropeptides. Narcolepsycataplexy is a chronic, debilitating sleep disorder that is characterized by excessive daytime sleepiness, manifested as attacks of daytime somnolence at inappropriate times. 1-3 Narcoleptics also show symptoms that are considered indicative of abnormal REM (Rapid Eye Movement) sleep expression. These latter symptoms include cataplexy, hypnogogic hallucinations, sleep-onset REM periods, and sleep paralysis. In contrast to daytime sleepiness, the nighttime sleep of narcoleptics is fragmented and of poor quality, typically demonstrating lengthy periods of wakefulness after sleep onset

Original languageEnglish (US)
Title of host publicationNeuroendocrine Correlates of Sleep/Wakefulness
PublisherSpringer US
Pages221-240
Number of pages20
ISBN (Print)9780387236926, 0387236414, 9780387236414
DOIs
StatePublished - 2006

Fingerprint

Wakefulness
Sleep
Cataplexy
REM Sleep
Sleep Paralysis
Narcolepsy
Hallucinations
Neuropeptides
Neurons
Research

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Sinton, C. M., & Willie, J. T. (2006). The influence of orexin on sleep and wakefulness. In Neuroendocrine Correlates of Sleep/Wakefulness (pp. 221-240). Springer US. https://doi.org/10.1007/0-387-23692-9_11

The influence of orexin on sleep and wakefulness. / Sinton, Christopher M.; Willie, Jon T.

Neuroendocrine Correlates of Sleep/Wakefulness. Springer US, 2006. p. 221-240.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sinton, CM & Willie, JT 2006, The influence of orexin on sleep and wakefulness. in Neuroendocrine Correlates of Sleep/Wakefulness. Springer US, pp. 221-240. https://doi.org/10.1007/0-387-23692-9_11
Sinton CM, Willie JT. The influence of orexin on sleep and wakefulness. In Neuroendocrine Correlates of Sleep/Wakefulness. Springer US. 2006. p. 221-240 https://doi.org/10.1007/0-387-23692-9_11
Sinton, Christopher M. ; Willie, Jon T. / The influence of orexin on sleep and wakefulness. Neuroendocrine Correlates of Sleep/Wakefulness. Springer US, 2006. pp. 221-240
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