The influence of orexin on sleep and wakefulness

Christopher M. Sinton, Jon T. Willie

Research output: Chapter in Book/Report/Conference proceedingChapter


An exciting recent development in sleep research was the discovery of the importance for vigilance state control and narcolepsy-cataplexy of neurons containing orexin (also known as hypocretin) neuropeptides. Narcolepsycataplexy is a chronic, debilitating sleep disorder that is characterized by excessive daytime sleepiness, manifested as attacks of daytime somnolence at inappropriate times. 1-3 Narcoleptics also show symptoms that are considered indicative of abnormal REM (Rapid Eye Movement) sleep expression. These latter symptoms include cataplexy, hypnogogic hallucinations, sleep-onset REM periods, and sleep paralysis. In contrast to daytime sleepiness, the nighttime sleep of narcoleptics is fragmented and of poor quality, typically demonstrating lengthy periods of wakefulness after sleep onset

Original languageEnglish (US)
Title of host publicationNeuroendocrine Correlates of Sleep/Wakefulness
PublisherSpringer US
Number of pages20
ISBN (Electronic)9780387236926
ISBN (Print)0387236414, 9780387236414
StatePublished - 2006

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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