Electrolytic damage of the nucleus reticularis tegmenti pontis (NRTP) in rats produces a form of accelerating forward locomotion, indicating that this region is part of a system that inhibits locomotion and movement. In animals with such damage, 5 mg/kg haloperidol does not block forward locomotion although it produces complete akinesia in normal rats . Our present results demonstrate that doses of morphine sulfate that render normal rats completely akinetic (40, 50, or 60 mg/kg) also fail to block forward locomotion. Furthermore, 200 μg γ-aminobutyric acid applied intracranially in the region of the NRTP can reverse the akinesia produced by systemically administered haloperidol or morphine. We suggest that there are two types of akinesia-direct and indirect-and that morphine and haloperidol may produce akinesia indirectly via an inhibitory system which includes the NRTP.
- Movement subsystems
- Nucleus reticularis tegmenti pontis
- Parkinson's disease
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience