The INO80 chromatin remodeling complex in transcription, replication and repair

Ronald C. Conaway, Joan Weliky Conaway

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations

Abstract

The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalTrends in biochemical sciences
Volume34
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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