Abstract
In this review, we have described the functional properties and regulation of the InsP3R. Not all aspects of InsP3R function and regulation were covered, the main focus was on the most recent and physiologically important data. Information about the structure, heterogeneity, functional properties, and regulation of the InsP3R is useful for understanding the spatiotemporal aspects of Ca signaling. The combination of biochemical, biophysical and molecular biological techniques has revealed the intricacies of the InsP3R over the past decade. However, questions about the functional differences between various isoforms and splice variants of the InsP3R, the structural determinants responsible for regulation of InsP3R by Ca and ATP, the functional effects of InsP3R phosphorylation and many others remain to be elucidated. Future investigations can be expected to provide answers to these important questions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 205-216 |
| Number of pages | 12 |
| Journal | The Journal of Membrane Biology |
| Volume | 145 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1995 |
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Keywords
- Calcium signaling
- Intracellular calcium release channel
- Ryanodine receptor
- Second messenger
ASJC Scopus subject areas
- Physiology
- Cell Biology
- Biophysics
Cite this
The inositol 1,4,5-trisphosphate (InsP3) receptor. / Bezprozvanny, I.; Ehrlich, B. E.
In: The Journal of Membrane Biology, Vol. 145, No. 3, 06.1995, p. 205-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The inositol 1,4,5-trisphosphate (InsP3) receptor
AU - Bezprozvanny, I.
AU - Ehrlich, B. E.
PY - 1995/6
Y1 - 1995/6
N2 - In this review, we have described the functional properties and regulation of the InsP3R. Not all aspects of InsP3R function and regulation were covered, the main focus was on the most recent and physiologically important data. Information about the structure, heterogeneity, functional properties, and regulation of the InsP3R is useful for understanding the spatiotemporal aspects of Ca signaling. The combination of biochemical, biophysical and molecular biological techniques has revealed the intricacies of the InsP3R over the past decade. However, questions about the functional differences between various isoforms and splice variants of the InsP3R, the structural determinants responsible for regulation of InsP3R by Ca and ATP, the functional effects of InsP3R phosphorylation and many others remain to be elucidated. Future investigations can be expected to provide answers to these important questions.
AB - In this review, we have described the functional properties and regulation of the InsP3R. Not all aspects of InsP3R function and regulation were covered, the main focus was on the most recent and physiologically important data. Information about the structure, heterogeneity, functional properties, and regulation of the InsP3R is useful for understanding the spatiotemporal aspects of Ca signaling. The combination of biochemical, biophysical and molecular biological techniques has revealed the intricacies of the InsP3R over the past decade. However, questions about the functional differences between various isoforms and splice variants of the InsP3R, the structural determinants responsible for regulation of InsP3R by Ca and ATP, the functional effects of InsP3R phosphorylation and many others remain to be elucidated. Future investigations can be expected to provide answers to these important questions.
KW - Calcium signaling
KW - Intracellular calcium release channel
KW - Ryanodine receptor
KW - Second messenger
UR - http://www.scopus.com/inward/record.url?scp=0029000508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029000508&partnerID=8YFLogxK
U2 - 10.1007/BF00232713
DO - 10.1007/BF00232713
M3 - Article
C2 - 7563022
AN - SCOPUS:0029000508
VL - 145
SP - 205
EP - 216
JO - Journal of Membrane Biology
JF - Journal of Membrane Biology
SN - 0022-2631
IS - 3
ER -