The inositol 1,4,5-trisphosphate receptors

Ilya Bezprozvanny

doi:10.1016/j.ceca.2005.06.030

The inositol 1,4,5-trisphosphate receptors

Ilya Bezprozvanny

Research output: Contribution to journal › Article › peer-review

190 Scopus citations

Abstract

The inositol (1,4,5)-trisphosphate receptors (InsP₃R) are the intracellular calcium (Ca²⁺) release channels that play a key role in Ca²⁺ signaling in cells. Three InsP₃R isoforms-InsP₃R type 1 (InsP₃R1), InsP₃ R type 2 (InsP₃R2), and InsP₃R type 3 (InsP₃R3) are expressed in mammals. A single InsP₃R isoform is expressed in Drosophila melanogaster (DmInsP₃R) and Caenorhabditis elegans (CeInsP₃R). The progress made during last decade towards understanding the function and the properties of the InsP₃R is briefly reviewed in this chapter. The main emphasis is on studies that revealed structural determinants responsible for the ligand recognition by the InsP₃R, ion permeability of the InsP₃R, modulation of the InsP₃R by cytosolic Ca²⁺, ATP and PKA phosphorylation and on the recently identified InsP₃R-binding partners. The main focus is on the InsP₃R1, but the recent information about properties of other InsP₃R isoforms is also discussed.

Original language	English (US)
Pages (from-to)	261-272
Number of pages	12
Journal	Cell Calcium
Volume	38
Issue number	3-4 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.ceca.2005.06.030
State	Published - 2005

Keywords

Calcium imaging
Calcium signaling
Ion channels
Mutagenesis
Planar lipid bilayers
Structure-function

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.ceca.2005.06.030

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title = "The inositol 1,4,5-trisphosphate receptors",

abstract = "The inositol (1,4,5)-trisphosphate receptors (InsP3R) are the intracellular calcium (Ca2+) release channels that play a key role in Ca2+ signaling in cells. Three InsP3R isoforms-InsP3R type 1 (InsP3R1), InsP3 R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals. A single InsP3R isoform is expressed in Drosophila melanogaster (DmInsP3R) and Caenorhabditis elegans (CeInsP3R). The progress made during last decade towards understanding the function and the properties of the InsP3R is briefly reviewed in this chapter. The main emphasis is on studies that revealed structural determinants responsible for the ligand recognition by the InsP3R, ion permeability of the InsP3R, modulation of the InsP3R by cytosolic Ca2+, ATP and PKA phosphorylation and on the recently identified InsP3R-binding partners. The main focus is on the InsP3R1, but the recent information about properties of other InsP3R isoforms is also discussed.",

keywords = "Calcium imaging, Calcium signaling, Ion channels, Mutagenesis, Planar lipid bilayers, Structure-function",

author = "Ilya Bezprozvanny",

note = "Funding Information: I am grateful to many talented students in my lab for their hard work and dedication, to Gregory Mignery and Thomas C. S{\"u}dhof for the kind gift of the rat InsP 3 R1 and InsP 3 R2 clones, to Dr. Graem Bell for the kind gift of the rat InsP 3 R3 clone, to Masamitsu Iino, Humbert De Smedt, and Gaiti Hasan for great collaborations and to Barbara Ehrlich for lots of encouragement and support. The InsP 3 R project in my laboratory is supported by the Welch Foundation and NIH R01 NS38082.",

year = "2005",

doi = "10.1016/j.ceca.2005.06.030",

language = "English (US)",

volume = "38",

pages = "261--272",

journal = "Cell Calcium",

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number = "3-4 SPEC. ISS.",

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AU - Bezprozvanny, Ilya

N1 - Funding Information: I am grateful to many talented students in my lab for their hard work and dedication, to Gregory Mignery and Thomas C. Südhof for the kind gift of the rat InsP 3 R1 and InsP 3 R2 clones, to Dr. Graem Bell for the kind gift of the rat InsP 3 R3 clone, to Masamitsu Iino, Humbert De Smedt, and Gaiti Hasan for great collaborations and to Barbara Ehrlich for lots of encouragement and support. The InsP 3 R project in my laboratory is supported by the Welch Foundation and NIH R01 NS38082.

PY - 2005

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AB - The inositol (1,4,5)-trisphosphate receptors (InsP3R) are the intracellular calcium (Ca2+) release channels that play a key role in Ca2+ signaling in cells. Three InsP3R isoforms-InsP3R type 1 (InsP3R1), InsP3 R type 2 (InsP3R2), and InsP3R type 3 (InsP3R3) are expressed in mammals. A single InsP3R isoform is expressed in Drosophila melanogaster (DmInsP3R) and Caenorhabditis elegans (CeInsP3R). The progress made during last decade towards understanding the function and the properties of the InsP3R is briefly reviewed in this chapter. The main emphasis is on studies that revealed structural determinants responsible for the ligand recognition by the InsP3R, ion permeability of the InsP3R, modulation of the InsP3R by cytosolic Ca2+, ATP and PKA phosphorylation and on the recently identified InsP3R-binding partners. The main focus is on the InsP3R1, but the recent information about properties of other InsP3R isoforms is also discussed.

KW - Calcium imaging

KW - Calcium signaling

KW - Ion channels

KW - Mutagenesis

KW - Planar lipid bilayers

KW - Structure-function

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JO - Cell Calcium

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IS - 3-4 SPEC. ISS.

ER -

The inositol 1,4,5-trisphosphate receptors

Abstract

Keywords

ASJC Scopus subject areas

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