The interaction of central command and the exercise pressor reflex in mediating baroreflex resetting during exercise in humans

Kevin M. Gallagher, Paul J. Fadel, Scott A. Smith, Morten Strømstad, Kojiro Ide, Niels H. Secher, Peter B. Raven

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Central command and the exercise pressor reflex can independently reset the carotid baroreflex (CBR) during exercise. The present investigation assessed the interactive relationship between these two neural mechanisms in mediating baroreflex resetting during exercise. Six men performed static leg exercise at 20% maximal voluntary contraction under four conditions: control, no perturbation; neuromuscular blockade (NMB) induced by administration of the neuromuscular blocking agent Norcuron (central command activation); MAST, application of medical antishock trousers inflated to 100 mmHg (exercise pressor reflex activation); and Combo, NMB plus MAST (concomitant central command and exercise pressor reflex activation). With regard to CBR control of heart rate (HR), both NMB and Combo conditions resulted in a further resetting of the carotid-cardiac stimulus-response curve compared to control conditions, suggesting that CBR-HR resetting is predominately mediated by central command. In contrast, it appears that CBR control of blood pressure can be mediated by signals from either central command or the exercise pressor reflex, since both NMB and MAST conditions equally augmented the resetting of the carotid-vasomotor stimulus-response curve. With regard to the regulation of both HR and blood pressure, the extent of CBR resetting was greater during the Combo condition than during overactivation of either central command or the exercise pressor reflex alone. Therefore, we suggest that central command and the exercise pressor reflex interact such that signals from one input facilitate signals from the other, resulting in an enhanced resetting of the baroreflex during exercise.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalExperimental Physiology
Volume91
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Baroreflex
Reflex
Exercise
Neuromuscular Blockade
Heart Rate
Gravity Suits
Blood Pressure
Neuromuscular Blocking Agents
Vecuronium Bromide
Leg

ASJC Scopus subject areas

  • Physiology

Cite this

The interaction of central command and the exercise pressor reflex in mediating baroreflex resetting during exercise in humans. / Gallagher, Kevin M.; Fadel, Paul J.; Smith, Scott A.; Strømstad, Morten; Ide, Kojiro; Secher, Niels H.; Raven, Peter B.

In: Experimental Physiology, Vol. 91, No. 1, 01.2006, p. 79-87.

Research output: Contribution to journalArticle

Gallagher, Kevin M. ; Fadel, Paul J. ; Smith, Scott A. ; Strømstad, Morten ; Ide, Kojiro ; Secher, Niels H. ; Raven, Peter B. / The interaction of central command and the exercise pressor reflex in mediating baroreflex resetting during exercise in humans. In: Experimental Physiology. 2006 ; Vol. 91, No. 1. pp. 79-87.
@article{a7b6d5251d4e4be785d69e4343d93808,
title = "The interaction of central command and the exercise pressor reflex in mediating baroreflex resetting during exercise in humans",
abstract = "Central command and the exercise pressor reflex can independently reset the carotid baroreflex (CBR) during exercise. The present investigation assessed the interactive relationship between these two neural mechanisms in mediating baroreflex resetting during exercise. Six men performed static leg exercise at 20{\%} maximal voluntary contraction under four conditions: control, no perturbation; neuromuscular blockade (NMB) induced by administration of the neuromuscular blocking agent Norcuron (central command activation); MAST, application of medical antishock trousers inflated to 100 mmHg (exercise pressor reflex activation); and Combo, NMB plus MAST (concomitant central command and exercise pressor reflex activation). With regard to CBR control of heart rate (HR), both NMB and Combo conditions resulted in a further resetting of the carotid-cardiac stimulus-response curve compared to control conditions, suggesting that CBR-HR resetting is predominately mediated by central command. In contrast, it appears that CBR control of blood pressure can be mediated by signals from either central command or the exercise pressor reflex, since both NMB and MAST conditions equally augmented the resetting of the carotid-vasomotor stimulus-response curve. With regard to the regulation of both HR and blood pressure, the extent of CBR resetting was greater during the Combo condition than during overactivation of either central command or the exercise pressor reflex alone. Therefore, we suggest that central command and the exercise pressor reflex interact such that signals from one input facilitate signals from the other, resulting in an enhanced resetting of the baroreflex during exercise.",
author = "Gallagher, {Kevin M.} and Fadel, {Paul J.} and Smith, {Scott A.} and Morten Str{\o}mstad and Kojiro Ide and Secher, {Niels H.} and Raven, {Peter B.}",
year = "2006",
month = "1",
doi = "10.1113/expphysiol.2005.032110",
language = "English (US)",
volume = "91",
pages = "79--87",
journal = "Experimental Physiology",
issn = "0958-0670",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The interaction of central command and the exercise pressor reflex in mediating baroreflex resetting during exercise in humans

AU - Gallagher, Kevin M.

AU - Fadel, Paul J.

AU - Smith, Scott A.

AU - Strømstad, Morten

AU - Ide, Kojiro

AU - Secher, Niels H.

AU - Raven, Peter B.

PY - 2006/1

Y1 - 2006/1

N2 - Central command and the exercise pressor reflex can independently reset the carotid baroreflex (CBR) during exercise. The present investigation assessed the interactive relationship between these two neural mechanisms in mediating baroreflex resetting during exercise. Six men performed static leg exercise at 20% maximal voluntary contraction under four conditions: control, no perturbation; neuromuscular blockade (NMB) induced by administration of the neuromuscular blocking agent Norcuron (central command activation); MAST, application of medical antishock trousers inflated to 100 mmHg (exercise pressor reflex activation); and Combo, NMB plus MAST (concomitant central command and exercise pressor reflex activation). With regard to CBR control of heart rate (HR), both NMB and Combo conditions resulted in a further resetting of the carotid-cardiac stimulus-response curve compared to control conditions, suggesting that CBR-HR resetting is predominately mediated by central command. In contrast, it appears that CBR control of blood pressure can be mediated by signals from either central command or the exercise pressor reflex, since both NMB and MAST conditions equally augmented the resetting of the carotid-vasomotor stimulus-response curve. With regard to the regulation of both HR and blood pressure, the extent of CBR resetting was greater during the Combo condition than during overactivation of either central command or the exercise pressor reflex alone. Therefore, we suggest that central command and the exercise pressor reflex interact such that signals from one input facilitate signals from the other, resulting in an enhanced resetting of the baroreflex during exercise.

AB - Central command and the exercise pressor reflex can independently reset the carotid baroreflex (CBR) during exercise. The present investigation assessed the interactive relationship between these two neural mechanisms in mediating baroreflex resetting during exercise. Six men performed static leg exercise at 20% maximal voluntary contraction under four conditions: control, no perturbation; neuromuscular blockade (NMB) induced by administration of the neuromuscular blocking agent Norcuron (central command activation); MAST, application of medical antishock trousers inflated to 100 mmHg (exercise pressor reflex activation); and Combo, NMB plus MAST (concomitant central command and exercise pressor reflex activation). With regard to CBR control of heart rate (HR), both NMB and Combo conditions resulted in a further resetting of the carotid-cardiac stimulus-response curve compared to control conditions, suggesting that CBR-HR resetting is predominately mediated by central command. In contrast, it appears that CBR control of blood pressure can be mediated by signals from either central command or the exercise pressor reflex, since both NMB and MAST conditions equally augmented the resetting of the carotid-vasomotor stimulus-response curve. With regard to the regulation of both HR and blood pressure, the extent of CBR resetting was greater during the Combo condition than during overactivation of either central command or the exercise pressor reflex alone. Therefore, we suggest that central command and the exercise pressor reflex interact such that signals from one input facilitate signals from the other, resulting in an enhanced resetting of the baroreflex during exercise.

UR - http://www.scopus.com/inward/record.url?scp=33645093709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645093709&partnerID=8YFLogxK

U2 - 10.1113/expphysiol.2005.032110

DO - 10.1113/expphysiol.2005.032110

M3 - Article

C2 - 16263799

AN - SCOPUS:33645093709

VL - 91

SP - 79

EP - 87

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

IS - 1

ER -