The interactions of adenylate cyclases with P-site inhibitors

Carmen W. Dessauer, John J G Tesmer, Stephen R. Sprang, Alfred G. Gilman

Research output: Contribution to journalReview article

81 Scopus citations

Abstract

Recent kinetic, binding and crystallographic studies using P-site inhibitors of mammalian adenylate cyclases provide new insights into the catalytic mechanism of these highly regulated enzymes. Here, Carmen Dessauer and colleagues discuss the conformational states of adenylate cyclase, the structural determinants of inhibitor binding and the potential uses of these inhibitors as pharmacological agents.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalTrends in Pharmacological Sciences
Volume20
Issue number5
DOIs
StatePublished - May 1 1999

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ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Dessauer, C. W., Tesmer, J. J. G., Sprang, S. R., & Gilman, A. G. (1999). The interactions of adenylate cyclases with P-site inhibitors. Trends in Pharmacological Sciences, 20(5), 205-210. https://doi.org/10.1016/S0165-6147(99)01310-3