Abstract
The interactions of gallium (Ga) with the ligands, EDTA, NTA, phosphate, lactate, MOPS, TRIS and HEPES are investigated using both 71Ga and 1H nmr measurements. Both EDTA and NTA form strong complexes with gallium, which have a 1:1 stoichiometry. In alkaline solution the tetrahedral Ga(OD)4 - competes strongly with EDTA in complex formation. In the lactate complex, there are probably three lactates per gallium present. The phosphate complexes of gallium are difficult to characterize on the basis of this investigation. The buffers, MOPS, TRIS, and HEPES, do not interact with gallium significantly. The ability of the ligands to bind gallium correlates well with their ability to inhibit gallium incorporation by L1210 leukemic cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-19 |
| Number of pages | 9 |
| Journal | Bioinorganic Chemistry |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1978 |
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ASJC Scopus subject areas
- Biochemistry
- Chemistry(all)
Cite this
The interactions of gallium with various buffers and chelating agents in aqueous solution : Gallium-71 and hydrogen-1 NMR studies. / Chang, C. H Francis; Pitner, T. Phil; Lenkinski, Robert E.; Glickson, Jerry D.
In: Bioinorganic Chemistry, Vol. 8, No. 1, 1978, p. 11-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The interactions of gallium with various buffers and chelating agents in aqueous solution
T2 - Gallium-71 and hydrogen-1 NMR studies
AU - Chang, C. H Francis
AU - Pitner, T. Phil
AU - Lenkinski, Robert E.
AU - Glickson, Jerry D.
PY - 1978
Y1 - 1978
N2 - The interactions of gallium (Ga) with the ligands, EDTA, NTA, phosphate, lactate, MOPS, TRIS and HEPES are investigated using both 71Ga and 1H nmr measurements. Both EDTA and NTA form strong complexes with gallium, which have a 1:1 stoichiometry. In alkaline solution the tetrahedral Ga(OD)4 - competes strongly with EDTA in complex formation. In the lactate complex, there are probably three lactates per gallium present. The phosphate complexes of gallium are difficult to characterize on the basis of this investigation. The buffers, MOPS, TRIS, and HEPES, do not interact with gallium significantly. The ability of the ligands to bind gallium correlates well with their ability to inhibit gallium incorporation by L1210 leukemic cells.
AB - The interactions of gallium (Ga) with the ligands, EDTA, NTA, phosphate, lactate, MOPS, TRIS and HEPES are investigated using both 71Ga and 1H nmr measurements. Both EDTA and NTA form strong complexes with gallium, which have a 1:1 stoichiometry. In alkaline solution the tetrahedral Ga(OD)4 - competes strongly with EDTA in complex formation. In the lactate complex, there are probably three lactates per gallium present. The phosphate complexes of gallium are difficult to characterize on the basis of this investigation. The buffers, MOPS, TRIS, and HEPES, do not interact with gallium significantly. The ability of the ligands to bind gallium correlates well with their ability to inhibit gallium incorporation by L1210 leukemic cells.
UR - http://www.scopus.com/inward/record.url?scp=0017838444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017838444&partnerID=8YFLogxK
U2 - 10.1016/S0006-3061(00)80001-0
DO - 10.1016/S0006-3061(00)80001-0
M3 - Article
C2 - 23867
AN - SCOPUS:0017838444
VL - 8
SP - 11
EP - 19
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
SN - 0162-0134
IS - 1
ER -