The international society for mild approaches in assisted reproduction (ISMAAR) definitions for mild stimulation and their rationale for assisted reproductive technologies

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In order to increase the oocyte yield from a single in vitro fertilization (IVF) cycle, controlled ovarian stimulation (COS) protocols were developed. Increased daily doses of follicle-stimulating hormone (FSH) products in conventional COS protocols brought concerns about their association with ovarian hyperstimulation syndrome, multiple pregnancies due to the transfer of increased number of embryos to achieve pregnancy, increased embryonic aneuploidy, and inferior IVF outcomes. This leads to revisiting milder stimulation protocols for IVF. The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) brought the definition for mild stimulation. Gentle approaches to IVF including natural cycle and mild and minimal stimulation protocols found acceptance especially in women with expected poor ovarian response, mostly due to diminished ovarian reserve and advanced reproductive age.

Original languageEnglish (US)
Title of host publicationDiminished Ovarian Reserve and Assisted Reproductive Technologies
Subtitle of host publicationCurrent Research and Clinical Management
PublisherSpringer International Publishing
Pages141-149
Number of pages9
ISBN (Electronic)9783030232351
ISBN (Print)9783030232344
DOIs
StatePublished - Jan 1 2019

Keywords

  • Advanced reproductive age
  • Assisted reproductive technology
  • ISMAAR
  • IVF
  • Mild stimulation
  • Poor ovarian response

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

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