The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

Yuhao Wang, Zheng Kuang, Xiaofei Yu, Kelly A. Ruhn, Masato Kubo, Lora V. Hooper

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The intestinal microbiota has been identified as an environmental factor that markedly affects energy storage and body-fat accumulation in mammals, yet the underlying mechanisms remain unclear. Here we show that the microbiota regulates body composition through the circadian transcription factor NFIL3. Nfil3 transcription oscillates diurnally in intestinal epithelial cells, and the amplitude of the circadian oscillation is controlled by the microbiota through group 3 innate lymphoid cells, STAT3 (signal transducer and activator of transcription 3), and the epithelial cell circadian clock. NFIL3 controls expression of a circadian lipid metabolic program and regulates lipid absorption and export in intestinal epithelial cells. These findings provide mechanistic insight into how the intestinal microbiota regulates body composition and establish NFIL3 as an essential molecular link among the microbiota, the circadian clock, and host metabolism.

Original languageEnglish (US)
Pages (from-to)912-916
Number of pages5
JournalScience
Volume357
Issue number6354
DOIs
StatePublished - Sep 1 2017

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Circadian Clocks
Microbiota
Body Composition
Epithelial Cells
Lipids
STAT3 Transcription Factor
Adipose Tissue
Mammals
Transcription Factors
Lymphocytes
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. / Wang, Yuhao; Kuang, Zheng; Yu, Xiaofei; Ruhn, Kelly A.; Kubo, Masato; Hooper, Lora V.

In: Science, Vol. 357, No. 6354, 01.09.2017, p. 912-916.

Research output: Contribution to journalArticle

Wang, Yuhao ; Kuang, Zheng ; Yu, Xiaofei ; Ruhn, Kelly A. ; Kubo, Masato ; Hooper, Lora V. / The intestinal microbiota regulates body composition through NFIL3 and the circadian clock. In: Science. 2017 ; Vol. 357, No. 6354. pp. 912-916.
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