The invertebrate odorant-binding protein LUSH is required for normal olfactory behavior in Drosophila

M. S. Kim, D. P. Smith

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The invertebrate odorant-binding proteins consist of a large family of low-molecular-weight, highly divergent proteins expressed exclusively in the chemosensory sensilla of insects. Each member of this family studied to date is secreted into the sensillum lymph of a small subset of sensilla by non-neuronal support cells. These expression patterns suggests an odor-specific function for these proteins as opposed to a general role in sensillum biology. Consistent with this notion, mutants defective for LUSH, a Drosophila member of this family, have odor-specific defects in olfactory behavior. The Drosophila genome contains at least 32 members of this gene family, rivaling the number of odorant receptors in this species. The relationship between these two protein families and how they act to determine odor specificity of olfactory neurons will be the topic of future studies.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalChemical Senses
Volume26
Issue number2
StatePublished - 2001

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Sensilla
sensilla
Invertebrates
Drosophila
invertebrates
odors
Odorant Receptors
Proteins
lymph
proteins
Lymph
Insects
Molecular Weight
neurons
Genome
molecular weight
Neurons
Biological Sciences
mutants
insects

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Neuroscience(all)
  • Physiology
  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

The invertebrate odorant-binding protein LUSH is required for normal olfactory behavior in Drosophila. / Kim, M. S.; Smith, D. P.

In: Chemical Senses, Vol. 26, No. 2, 2001, p. 195-199.

Research output: Contribution to journalArticle

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