The Kidney and Planar Cell Polarity

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Planar cell polarity (PCP) or tissue polarity describes a coordinated polarity at the plane of the tissue where most or all cells within a tissue are polarized in one direction. It is perpendicular to the apical-basal polarity of the cell. PCP is manifested readily in the Drosophila wing and cuticle bristles, Drosophila eye ommatidia, and mammalian hair and inner ear hair bundles, and less evidently, in cellular processes such as in the coordinated, directional cell movements, and oriented cell divisions that are important for tissue morphogenesis. Several distinct molecular and cellular processes have been implicated in the regulation of PCP. Here, we review potential roles for PCP during mouse kidney development and maintenance, including ureteric bud branching morphogenesis, renal medulla elongation, tubule diameter establishment/maintenance, glomerulogenesis, and response to injury. The potential mechanisms underlying these processes, including oriented cell division and coordinated cell migration/cell intercalation, are discussed. In addition, we discuss some unaddressed research topics related to PCP in the kidney that we hope will spur further discussion and investigation.

Original languageEnglish (US)
Pages (from-to)185-212
Number of pages28
JournalCurrent Topics in Developmental Biology
Volume101
DOIs
StatePublished - 2012

Keywords

  • Cell intercalation
  • Kidney
  • Oriented cell division
  • Planar cell polarity
  • Primary cilium
  • Tubular repair

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

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