TY - JOUR
T1 - The Kidney in Congenital Ureteropelvic Junction Obstruction
T2 - A Spectrum From Normal to Nephrectomy
AU - Rosen, Seymour
AU - Peters, Craig A
AU - Chevalier, Robert L.
AU - Huang, Weei Yuan
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Purpose: Our recent studies of renal histology in congenital ureteropelvic obstruction cases prompted us to review the literature in this regard, focusing on issues of development, normal variation, clinicopathological correlations and pathogenesis. Materials and Methods: The period from 1971 to 2006 was analyzed, including all relevant articles, which were critically reviewed. Results: There have been many studies encompassing the entity of ureteropelvic junction obstruction that include clinical findings, radiographic imaging, pathological examination of ureteropelvic junction obstruction per se and renal biopsies during pyeloplasty procedures. We synthesized this information in a cohesive review with a proposed classification. Conclusions: Congenital ureteropelvic junction obstruction is a spectrum that ranges from the radiological demonstration of apparent physiological ureteropelvic junction obstruction to a disordered ureteropelvic junction, characterized by smooth muscle hypertrophy and fibrosis associated with renal parenchymal changes that may necessitate pyeloplasty or nephrectomy. However, renal biopsies in patients in whom pyeloplasty is done show in most of them relatively well maintained parenchyma, in which overt changes are mainly glomerular. More subtle alterations have been described that relate to shifts in proximal-to-distal tubular ratios. Extreme thinning of the renal parenchyma can occur with only limited tubulointerstitial injury. Recently ureteropelvic junction obstruction was described in a series of genetically altered animals and placed in a more global context, ie CAKUT (congenital abnormalities of the kidney and urinary tract).
AB - Purpose: Our recent studies of renal histology in congenital ureteropelvic obstruction cases prompted us to review the literature in this regard, focusing on issues of development, normal variation, clinicopathological correlations and pathogenesis. Materials and Methods: The period from 1971 to 2006 was analyzed, including all relevant articles, which were critically reviewed. Results: There have been many studies encompassing the entity of ureteropelvic junction obstruction that include clinical findings, radiographic imaging, pathological examination of ureteropelvic junction obstruction per se and renal biopsies during pyeloplasty procedures. We synthesized this information in a cohesive review with a proposed classification. Conclusions: Congenital ureteropelvic junction obstruction is a spectrum that ranges from the radiological demonstration of apparent physiological ureteropelvic junction obstruction to a disordered ureteropelvic junction, characterized by smooth muscle hypertrophy and fibrosis associated with renal parenchymal changes that may necessitate pyeloplasty or nephrectomy. However, renal biopsies in patients in whom pyeloplasty is done show in most of them relatively well maintained parenchyma, in which overt changes are mainly glomerular. More subtle alterations have been described that relate to shifts in proximal-to-distal tubular ratios. Extreme thinning of the renal parenchyma can occur with only limited tubulointerstitial injury. Recently ureteropelvic junction obstruction was described in a series of genetically altered animals and placed in a more global context, ie CAKUT (congenital abnormalities of the kidney and urinary tract).
KW - kidney
KW - kidney pelvis
KW - ureter
KW - ureteral obstruction
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U2 - 10.1016/j.juro.2007.11.048
DO - 10.1016/j.juro.2007.11.048
M3 - Review article
C2 - 18280506
AN - SCOPUS:40849111273
SN - 0022-5347
VL - 179
SP - 1257
EP - 1263
JO - Journal of Urology
JF - Journal of Urology
IS - 4
ER -