Abstract
The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis. It has been shown that Klotho-deficient mice and Fgf23 knockout mice exhibit identical phenotypes. This observation led to the identification of Klotho as a cofactor essential for interactions between FGF23 and FGF receptors. In addition to the Klotho-FGF23 axis, recent studies has shown that βKlotho, a Klotho family protein, also functions as a cofactor required for FGF19 and FGF21 signaling and determines the tissue-specific metabolic activities of FGF19 and FGF21. This review summarizes recent progress in understanding of Klotho and βKlotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23).
Original language | English (US) |
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Pages (from-to) | 72-78 |
Number of pages | 7 |
Journal | Molecular and Cellular Endocrinology |
Volume | 299 |
Issue number | 1 |
DOIs | |
State | Published - Feb 5 2009 |
Keywords
- FGF15
- FGF19
- FGF21
- FGF23
- Klotho
- Metabolism
- βKlotho
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology