The Klotho gene family as a regulator of endocrine fibroblast growth factors

Hiroshi Kurosu, Makoto Kuro-o

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis. It has been shown that Klotho-deficient mice and Fgf23 knockout mice exhibit identical phenotypes. This observation led to the identification of Klotho as a cofactor essential for interactions between FGF23 and FGF receptors. In addition to the Klotho-FGF23 axis, recent studies has shown that βKlotho, a Klotho family protein, also functions as a cofactor required for FGF19 and FGF21 signaling and determines the tissue-specific metabolic activities of FGF19 and FGF21. This review summarizes recent progress in understanding of Klotho and βKlotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23).

Original languageEnglish (US)
Pages (from-to)72-78
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume299
Issue number1
DOIs
StatePublished - Feb 5 2009

Fingerprint

Fibroblast Growth Factors
Genes
Fibroblast Growth Factor Receptors
Aging of materials
Tissue
Suppressor Genes
Phenotype
Knockout Mice
Vitamin D
Bone
Proteins
Homeostasis
Phosphates
Hormones
Bone and Bones
fibroblast growth factor 23
fibroblast growth factor 21

Keywords

  • βKlotho
  • FGF15
  • FGF19
  • FGF21
  • FGF23
  • Klotho
  • Metabolism

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

The Klotho gene family as a regulator of endocrine fibroblast growth factors. / Kurosu, Hiroshi; Kuro-o, Makoto.

In: Molecular and Cellular Endocrinology, Vol. 299, No. 1, 05.02.2009, p. 72-78.

Research output: Contribution to journalArticle

Kurosu, Hiroshi ; Kuro-o, Makoto. / The Klotho gene family as a regulator of endocrine fibroblast growth factors. In: Molecular and Cellular Endocrinology. 2009 ; Vol. 299, No. 1. pp. 72-78.
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