The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo

Lance P. Ford, Jerry W. Shay, Woodring E. Wright

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

La is an important component of ribonucleoprotein complexes and telomerase is a ribonucleoprotein that compensates for the shortening of the ends of linear DNA by adding telomeric repeats onto the ends of chromosomes by using an integral RNA as the template. We have identified a direct and specific interaction between La and the RNA component of human telomerase. Antibodies specific to La precipitate the human telomerase ribonucleoprotein complex derived from tumor cells, telomerase immortalized normal cells, and in vitro transformed cells. Overexpression of La in both experimentally immortalized human cells and prostate cancer cells results in gradual telomere shortening. Our results demonstrate that La can associate with telomerase and its expression level can influence telomere homeostasis in vivo.

Original languageEnglish (US)
Pages (from-to)1068-1075
Number of pages8
JournalRNA
Volume7
Issue number8
DOIs
StatePublished - 2001

Keywords

  • Aging
  • Autoimmunity
  • Cancer
  • RNP
  • Telomere length homeostasis
  • hTR

ASJC Scopus subject areas

  • Molecular Biology

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