600 Citations (Scopus)

Abstract

In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume29
Issue number4
DOIs
StatePublished - Apr 1 2009

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LDL Receptors
Myocardial Infarction
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Endocytosis
Cell Biology
History
Cholesterol

Keywords

  • Cholesterol
  • Coronary heart disease
  • Familial hypercholesterolemia
  • Receptor-mediated endocytosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The LDL receptor. / Goldstein, Joseph L.; Brown, Michael S.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 29, No. 4, 01.04.2009, p. 431-438.

Research output: Contribution to journalArticle

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