The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development

Joachim Herz, Robert V. Farese

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In recent years, a number of genes that are involved in cholesterol synthesis, its systemic or intercellular transport or lipid metabolism in general have been found to play important roles during embryonic development. In this article, we present a brief overview of these genes, their molecular functions as we understand them to date and our current interpretation of possible mechanisms by which genetic deficiency states might affect the development of the embryo, in particular the formation of the central nervous system.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume129
Issue number2 SUPPL.
StatePublished - 1999

Fingerprint

apolipoprotein B
LDL Receptors
Apolipoproteins B
Embryonic Development
embryogenesis
Cholesterol
cholesterol
receptors
Lipid Metabolism
lipid metabolism
Genes
central nervous system
genes
Central Nervous System
synthesis

Keywords

  • Central nervous system
  • Exencephaly
  • Hedgehog
  • LRP
  • Scavenger receptor class B type I

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development. / Herz, Joachim; Farese, Robert V.

In: Journal of Nutrition, Vol. 129, No. 2 SUPPL., 1999.

Research output: Contribution to journalArticle

@article{8e17a0790c8f49738f6d45b471c7e099,
title = "The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development",
abstract = "In recent years, a number of genes that are involved in cholesterol synthesis, its systemic or intercellular transport or lipid metabolism in general have been found to play important roles during embryonic development. In this article, we present a brief overview of these genes, their molecular functions as we understand them to date and our current interpretation of possible mechanisms by which genetic deficiency states might affect the development of the embryo, in particular the formation of the central nervous system.",
keywords = "Central nervous system, Exencephaly, Hedgehog, LRP, Scavenger receptor class B type I",
author = "Joachim Herz and Farese, {Robert V.}",
year = "1999",
language = "English (US)",
volume = "129",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "2 SUPPL.",

}

TY - JOUR

T1 - The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development

AU - Herz, Joachim

AU - Farese, Robert V.

PY - 1999

Y1 - 1999

N2 - In recent years, a number of genes that are involved in cholesterol synthesis, its systemic or intercellular transport or lipid metabolism in general have been found to play important roles during embryonic development. In this article, we present a brief overview of these genes, their molecular functions as we understand them to date and our current interpretation of possible mechanisms by which genetic deficiency states might affect the development of the embryo, in particular the formation of the central nervous system.

AB - In recent years, a number of genes that are involved in cholesterol synthesis, its systemic or intercellular transport or lipid metabolism in general have been found to play important roles during embryonic development. In this article, we present a brief overview of these genes, their molecular functions as we understand them to date and our current interpretation of possible mechanisms by which genetic deficiency states might affect the development of the embryo, in particular the formation of the central nervous system.

KW - Central nervous system

KW - Exencephaly

KW - Hedgehog

KW - LRP

KW - Scavenger receptor class B type I

UR - http://www.scopus.com/inward/record.url?scp=0032908113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032908113&partnerID=8YFLogxK

M3 - Article

VL - 129

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 2 SUPPL.

ER -