The LDL-receptor-related protein - Portrait of a multifunctional receptor

Research output: Contribution to journalArticle

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Abstract

The LDL-receptor-related protein is a multifunctional clearance receptor that removes remnant lipoproteins and proteases from the extracellular space. In the absence of functional receptors, mouse embryos fail early in development, probably as a result of a failure to clear protease/antiprotease complexes from the surface of the invading trophoblast. A receptor-associated protein blocks the binding of all ligands and appears to function as a rapid regulator of receptor activity.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalCurrent Opinion in Lipidology
Volume4
Issue number2
StatePublished - 1993

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Low Density Lipoprotein Receptor-Related Protein-1
Peptide Hydrolases
Trophoblasts
Extracellular Space
Protease Inhibitors
Protein Binding
Lipoproteins
Embryonic Structures
Ligands
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The LDL-receptor-related protein - Portrait of a multifunctional receptor. / Herz, Joachim.

In: Current Opinion in Lipidology, Vol. 4, No. 2, 1993, p. 107-113.

Research output: Contribution to journalArticle

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