The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases

Marcin Gradowski, Krzysztof Pawlowski

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.

Original languageEnglish (US)
Article numbere3849
JournalPeerJ
Volume2017
Issue number9
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Bacterial effectors
  • Mitochondrial carriers
  • Proteases
  • Structure prediction

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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