The level of plasma amyloid-β 40 is correlated with peripheral transport proteins in cognitively normal adults: A population-based cross-sectional study

Ling Gao, Yu Jiang, Shan Wei, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang, Rong Zhang, Qiumin Qu

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: Transport proteins, soluble low-density lipoprotein receptor-related protein-1 (sLRP1), and soluble receptor of advanced glycation end products (sRAGE), play an important role in the clearance of plasma amyloid-β (Aβ). However, their relationship is not clear. Objective: The aim was to explore the relationship between plasma levels of sLRP1, sRAGE, and Aβ in a cross-sectional study. Methods: A total of 1,185 cognitively normal participants (age above 40) from a village in the suburbs of Xi'an, China were enrolled from October 8, 2014 to March 30, 2015. Plasma Aβ 40, Aβ 42, sLRP1, and sRAGE were tested using a commercial ELISA. Apolipoprotein E (APOE) genotyping was conducted using PCR and sequencing. The relationship between plasma levels of sLRP1, sRAGE, and Aβ was analyzed using Pearson's correlation analysis and multiple linear regression. Results: In the total population, Log sLRP1 and Log sRAGE were positively correlated with plasma Aβ 40 (r= 0.103, p < 0.001; r= 0.064, p = 0.027, respectively), but neither were associated with plasma Aβ 42. After multivariable adjustment in the regression model, Log sLRP1 and Log sRAGE were still positively related with plasma Aβ 40 (β= 2.969, p < 0.001; β= 1.936, p = 0.017, respectively) but not Aβ 42. Furthermore, the positive correlations between transport proteins and plasma Aβ 40 remained significant only in APOE ϵ4 non-carriers after Pearson's analysis and multiple regression analysis after stratification by gene status. Conclusion: The concentrations of plasma sLRP1 and sRAGE had a significant impact on the level of plasma Aβ 40 in cognitively normal adults, especially in APOE ϵ4 non-carriers. However, the mechanism by which the transport proteins are involved in peripheral Aβ clearance and the relationship between transporters and amyloid burden in the brain needs further validation.

Original languageEnglish (US)
Pages (from-to)951-961
Number of pages11
JournalJournal of Alzheimer's Disease
Volume65
Issue number3
DOIs
StatePublished - Jan 1 2018

Keywords

  • Alzheimer's disease
  • amyloid-β
  • soluble low-density lipoprotein receptor-related protein-1 (sLRP1)
  • soluble receptor of advanced glycation end products (sRAGE)
  • transport proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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