The LIFE Cognition Study

Design and baseline characteristics

Kaycee M. Sink, Mark A. Espeland, Julia Rushing, Cynthia M. Castro, Timothy S. Church, Ronald Cohen, Thomas M. Gill, Leora Henkin, Janine M. Jennings, Diana R. Kerwin, Todd M. Manini, Valerie Myers, Marco Pahor, Kieran F. Reid, Nancy Woolard, Stephen R. Rapp, Jeff D. Williamson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Observational studies have shown beneficial relationships between exercise and cognitive function. Some clinical trials have also demonstrated improvements in cognitive function in response to moderate–high intensity aerobic exercise; however, these have been limited by relatively small sample sizes and short durations. The Lifestyle Interventions and Independence for Elders (LIFE) Study is the largest and longest randomized controlled clinical trial of physical activity with cognitive outcomes, in older sedentary adults at increased risk for incident mobility disability. One LIFE Study objective is to evaluate the effects of a structured physical activity program on changes in cognitive function and incident all-cause mild cognitive impairment or dementia. Here, we present the design and baseline cognitive data. At baseline, participants completed the modified Mini Mental Status Examination, Hopkins Verbal Learning Test, Digit Symbol Coding, Modified Rey–Osterrieth Complex Figure, and a computerized battery, selected to be sensitive to changes in speed of processing and executive functioning. During follow up, participants completed the same battery, along with the Category Fluency for Animals, Boston Naming, and Trail Making tests. The description of the mild cognitive impairment/dementia adjudication process is presented here. Participants with worse baseline Short Physical Performance Battery scores (prespecified at ≤ 7) had significantly lower median cognitive test scores compared with those having scores of 8 or 9 with modified Mini Mental Status Examination score of 91 versus (vs) 93, Hopkins Verbal Learning Test delayed recall score of 7.4 vs 7.9, and Digit Symbol Coding score of 45 vs 48, respectively (all P< 0.001). The LIFE Study will contribute important information on the effects of a structured physical activity program on cognitive outcomes in sedentary older adults at particular risk for mobility impairment. In addition to its importance in the area of prevention of cognitive decline, the LIFE Study will also likely serve as a model for exercise and other behavioral intervention trials in older adults.

Original languageEnglish (US)
Pages (from-to)1425-1436
Number of pages12
JournalClinical Interventions in Aging
Volume9
DOIs
StatePublished - Sep 3 2014

Fingerprint

Cognition
Life Style
Verbal Learning
Dementia
Trail Making Test
Sample Size
Observational Studies
Randomized Controlled Trials
Clinical Trials
Exercise
Cognitive Dysfunction

Keywords

  • Dementia
  • Exercise
  • Older adults
  • Physical activity

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Sink, K. M., Espeland, M. A., Rushing, J., Castro, C. M., Church, T. S., Cohen, R., ... Williamson, J. D. (2014). The LIFE Cognition Study: Design and baseline characteristics. Clinical Interventions in Aging, 9, 1425-1436. https://doi.org/10.2147/CIA.S65381

The LIFE Cognition Study : Design and baseline characteristics. / Sink, Kaycee M.; Espeland, Mark A.; Rushing, Julia; Castro, Cynthia M.; Church, Timothy S.; Cohen, Ronald; Gill, Thomas M.; Henkin, Leora; Jennings, Janine M.; Kerwin, Diana R.; Manini, Todd M.; Myers, Valerie; Pahor, Marco; Reid, Kieran F.; Woolard, Nancy; Rapp, Stephen R.; Williamson, Jeff D.

In: Clinical Interventions in Aging, Vol. 9, 03.09.2014, p. 1425-1436.

Research output: Contribution to journalArticle

Sink, KM, Espeland, MA, Rushing, J, Castro, CM, Church, TS, Cohen, R, Gill, TM, Henkin, L, Jennings, JM, Kerwin, DR, Manini, TM, Myers, V, Pahor, M, Reid, KF, Woolard, N, Rapp, SR & Williamson, JD 2014, 'The LIFE Cognition Study: Design and baseline characteristics', Clinical Interventions in Aging, vol. 9, pp. 1425-1436. https://doi.org/10.2147/CIA.S65381
Sink KM, Espeland MA, Rushing J, Castro CM, Church TS, Cohen R et al. The LIFE Cognition Study: Design and baseline characteristics. Clinical Interventions in Aging. 2014 Sep 3;9:1425-1436. https://doi.org/10.2147/CIA.S65381
Sink, Kaycee M. ; Espeland, Mark A. ; Rushing, Julia ; Castro, Cynthia M. ; Church, Timothy S. ; Cohen, Ronald ; Gill, Thomas M. ; Henkin, Leora ; Jennings, Janine M. ; Kerwin, Diana R. ; Manini, Todd M. ; Myers, Valerie ; Pahor, Marco ; Reid, Kieran F. ; Woolard, Nancy ; Rapp, Stephen R. ; Williamson, Jeff D. / The LIFE Cognition Study : Design and baseline characteristics. In: Clinical Interventions in Aging. 2014 ; Vol. 9. pp. 1425-1436.
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