TY - JOUR
T1 - The life cycle of lipid droplets
AU - Hashemi, Hayaa F.
AU - Goodman, Joel M.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Proteomic studies have revealed many potential functions of cytoplasmic lipid droplets, and recent activity has confirmed that these bona fide organelles are central not only for lipid storage and metabolism, but for development, immunity, and pathogenesis by several microbes. There has been a burst of recent activity on the assembly, maintenance and turnover of lipid droplets that reveals fresh insights. This review summarizes several novel findings in initiation of lipid droplet assembly, protein targeting, droplet fusion, and turnover of droplets through lipophagy.
AB - Proteomic studies have revealed many potential functions of cytoplasmic lipid droplets, and recent activity has confirmed that these bona fide organelles are central not only for lipid storage and metabolism, but for development, immunity, and pathogenesis by several microbes. There has been a burst of recent activity on the assembly, maintenance and turnover of lipid droplets that reveals fresh insights. This review summarizes several novel findings in initiation of lipid droplet assembly, protein targeting, droplet fusion, and turnover of droplets through lipophagy.
UR - http://www.scopus.com/inward/record.url?scp=84923057734&partnerID=8YFLogxK
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U2 - 10.1016/j.ceb.2015.02.002
DO - 10.1016/j.ceb.2015.02.002
M3 - Review article
C2 - 25703629
AN - SCOPUS:84923057734
SN - 0955-0674
VL - 33
SP - 119
EP - 124
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -