The Link Between Allergic Rhinitis and Chronic Otitis Media with Effusion in Atopic Patients

Amber Luong; Peter S. Roland

doi:10.1016/j.otc.2007.11.004

The Link Between Allergic Rhinitis and Chronic Otitis Media with Effusion in Atopic Patients

Amber Luong, Peter S. Roland

Otolaryngology - Head And Neck Surgery

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

The significant incidence of atopy associated with otitis media with effusion (OME) has suggested a role of allergy in the pathogenesis of OME. Analysis of inflammatory mediators indicates that the mucosa of the middle ear can respond to antigen in the same way as does the mucosa of the lower respiratory tract. Recent characterization of the mucosa and effusion from atopic patients with OME reveals a Th2 cytokine and cellular profiles consistent with an allergic response, supporting the role of allergy in OME. In addition, animal studies demonstrate that inhibiting characteristic allergy cytokines can prevent the production of middle ear effusion. As the understanding of allergy and its role in the inflammation of OME continues to deepen, this will introduce focused treatments of OME in the atopic population.

Original language	English (US)
Pages (from-to)	311-323
Number of pages	13
Journal	Otolaryngologic Clinics of North America
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.otc.2007.11.004
State	Published - Apr 2008

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.otc.2007.11.004

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abstract = "The significant incidence of atopy associated with otitis media with effusion (OME) has suggested a role of allergy in the pathogenesis of OME. Analysis of inflammatory mediators indicates that the mucosa of the middle ear can respond to antigen in the same way as does the mucosa of the lower respiratory tract. Recent characterization of the mucosa and effusion from atopic patients with OME reveals a Th2 cytokine and cellular profiles consistent with an allergic response, supporting the role of allergy in OME. In addition, animal studies demonstrate that inhibiting characteristic allergy cytokines can prevent the production of middle ear effusion. As the understanding of allergy and its role in the inflammation of OME continues to deepen, this will introduce focused treatments of OME in the atopic population.",

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AB - The significant incidence of atopy associated with otitis media with effusion (OME) has suggested a role of allergy in the pathogenesis of OME. Analysis of inflammatory mediators indicates that the mucosa of the middle ear can respond to antigen in the same way as does the mucosa of the lower respiratory tract. Recent characterization of the mucosa and effusion from atopic patients with OME reveals a Th2 cytokine and cellular profiles consistent with an allergic response, supporting the role of allergy in OME. In addition, animal studies demonstrate that inhibiting characteristic allergy cytokines can prevent the production of middle ear effusion. As the understanding of allergy and its role in the inflammation of OME continues to deepen, this will introduce focused treatments of OME in the atopic population.

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The Link Between Allergic Rhinitis and Chronic Otitis Media with Effusion in Atopic Patients

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