The lipid droplet-a well-connected organelle

Qiang Gao, Joel M Goodman

Research output: Contribution to journalReview article

101 Scopus citations

Abstract

Our knowledge of inter-organellar communication has grown exponentially in recent years. This review focuses on the interactions that cytoplasmic lipid droplets have with other organelles. Twenty-five years ago droplets were considered simply particles of coalesced fat. Ten years ago there were hints from proteomics studies that droplets might interact with other structures to share lipids and proteins. Now it is clear that the droplets interact with many if not most cellular structures to maintain cellular homeostasis and to buffer against insults such as starvation. The evidence for this statement, as well as probes to understand the nature and results of droplet interactions, are presented.

Original languageEnglish (US)
Article number49
JournalFrontiers in Cell and Developmental Biology
Volume3
Issue numberAUG
DOIs
StatePublished - Aug 12 2015

Keywords

  • Endoplasmic reticulum
  • Lipid droplet
  • Mitochondria
  • Organelle junction
  • Protein trafficking

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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