The lipid layer of tears: Dependent on meibomian gland function

James P McCulley, Ward E. Shine

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

There is growing laboratory and clinical evidence implicating the meibomian glands of the eyelid as playing a critical role in the pathogenesis of various ocular surface disorders such as chronic blepharitis and dry eye. Meibomian glands produce a lipid material whose synthesis is dependent on factors such as stem cells, neurological stimulants and hormones. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier, and must remain functional after a blink. Before delivery it can be modified by factors such as hormone abnormalities and even after delivery it may be modified by lipases produced by ocular bacteria.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalExperimental Eye Research
Volume78
Issue number3
DOIs
StatePublished - Mar 2004

Fingerprint

Meibomian Glands
Tears
Lipids
Blepharitis
Hormones
Eyelids
Lipase
Surface-Active Agents
Stem Cells
Bacteria

Keywords

  • Chronic blepharitis
  • Dry eye
  • Lipids
  • Meibomian gland
  • Tear film

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

The lipid layer of tears : Dependent on meibomian gland function. / McCulley, James P; Shine, Ward E.

In: Experimental Eye Research, Vol. 78, No. 3, 03.2004, p. 361-365.

Research output: Contribution to journalArticle

@article{feef7d5f636f4d929974024a8e929ca6,
title = "The lipid layer of tears: Dependent on meibomian gland function",
abstract = "There is growing laboratory and clinical evidence implicating the meibomian glands of the eyelid as playing a critical role in the pathogenesis of various ocular surface disorders such as chronic blepharitis and dry eye. Meibomian glands produce a lipid material whose synthesis is dependent on factors such as stem cells, neurological stimulants and hormones. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier, and must remain functional after a blink. Before delivery it can be modified by factors such as hormone abnormalities and even after delivery it may be modified by lipases produced by ocular bacteria.",
keywords = "Chronic blepharitis, Dry eye, Lipids, Meibomian gland, Tear film",
author = "McCulley, {James P} and Shine, {Ward E.}",
year = "2004",
month = "3",
doi = "10.1016/S0014-4835(03)00203-3",
language = "English (US)",
volume = "78",
pages = "361--365",
journal = "Experimental Eye Research",
issn = "0014-4835",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - The lipid layer of tears

T2 - Dependent on meibomian gland function

AU - McCulley, James P

AU - Shine, Ward E.

PY - 2004/3

Y1 - 2004/3

N2 - There is growing laboratory and clinical evidence implicating the meibomian glands of the eyelid as playing a critical role in the pathogenesis of various ocular surface disorders such as chronic blepharitis and dry eye. Meibomian glands produce a lipid material whose synthesis is dependent on factors such as stem cells, neurological stimulants and hormones. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier, and must remain functional after a blink. Before delivery it can be modified by factors such as hormone abnormalities and even after delivery it may be modified by lipases produced by ocular bacteria.

AB - There is growing laboratory and clinical evidence implicating the meibomian glands of the eyelid as playing a critical role in the pathogenesis of various ocular surface disorders such as chronic blepharitis and dry eye. Meibomian glands produce a lipid material whose synthesis is dependent on factors such as stem cells, neurological stimulants and hormones. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier, and must remain functional after a blink. Before delivery it can be modified by factors such as hormone abnormalities and even after delivery it may be modified by lipases produced by ocular bacteria.

KW - Chronic blepharitis

KW - Dry eye

KW - Lipids

KW - Meibomian gland

KW - Tear film

UR - http://www.scopus.com/inward/record.url?scp=0842267116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842267116&partnerID=8YFLogxK

U2 - 10.1016/S0014-4835(03)00203-3

DO - 10.1016/S0014-4835(03)00203-3

M3 - Article

C2 - 15106913

AN - SCOPUS:0842267116

VL - 78

SP - 361

EP - 365

JO - Experimental Eye Research

JF - Experimental Eye Research

SN - 0014-4835

IS - 3

ER -