The liver in metabolic syndrome

Simona D’amore, Giuseppe Palasciano, Antonio Moschetta

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The liver plays a major role in the regulation of pathways that govern systemic metabolic homeostasis. Hepatic regulation of glucose and lipid homeostasis is under the control of a complex system of hormones, transcription factors, and signaling pathways. Hepatic steatosis is a condition characterized by an increased amount of fat in the liver, mainly in the form of triglycerides, in a quantity greater than 5% of liver weight, or histologically defined when 5% or more of hepatocytes contains visible intracellular triglycerides, that cannot be attributed to alcohol consumption. Fatty liver is closely related to impairment in glucose, fatty acid, and lipoprotein metabolism, and it is now widely recognized as the hepatic manifestation of the Metabolic Syndrome. In the present chapter we will critically present the potential mechanisms that link obesity, type 2 diabetes, hepatic lipid accumulation, and insulin resistance. Indeed, although the correlation between fatty liver and insulin resistance is well established, we will specifically discuss the combination of elevated serum levels of glucose, fatty acids, and peripheral insulin resistance for the pathogenesis of liver dysfunction in the Metabolic Syndrome.

Original languageEnglish (US)
Title of host publicationA Systems Biology Approach to Study Metabolic Syndrome
PublisherSpringer International Publishing
Pages27-61
Number of pages35
ISBN (Print)9783319010083, 9783319010076
DOIs
StatePublished - Jan 1 2014

Fingerprint

Liver
Insulin Resistance
Fatty Liver
Glucose
Triglycerides
Homeostasis
Fatty Acids
Lipids
Alcohol Drinking
Vascular Resistance
Type 2 Diabetes Mellitus
Lipoproteins
Liver Diseases
Hepatocytes
Transcription Factors
Obesity
Fats
Hormones
Weights and Measures
Serum

Keywords

  • Insulin resistance
  • Lipid metabolism
  • Metabolic syndrome
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

D’amore, S., Palasciano, G., & Moschetta, A. (2014). The liver in metabolic syndrome. In A Systems Biology Approach to Study Metabolic Syndrome (pp. 27-61). Springer International Publishing. https://doi.org/10.1007/978-3-319-01008-3_3

The liver in metabolic syndrome. / D’amore, Simona; Palasciano, Giuseppe; Moschetta, Antonio.

A Systems Biology Approach to Study Metabolic Syndrome. Springer International Publishing, 2014. p. 27-61.

Research output: Chapter in Book/Report/Conference proceedingChapter

D’amore, S, Palasciano, G & Moschetta, A 2014, The liver in metabolic syndrome. in A Systems Biology Approach to Study Metabolic Syndrome. Springer International Publishing, pp. 27-61. https://doi.org/10.1007/978-3-319-01008-3_3
D’amore S, Palasciano G, Moschetta A. The liver in metabolic syndrome. In A Systems Biology Approach to Study Metabolic Syndrome. Springer International Publishing. 2014. p. 27-61 https://doi.org/10.1007/978-3-319-01008-3_3
D’amore, Simona ; Palasciano, Giuseppe ; Moschetta, Antonio. / The liver in metabolic syndrome. A Systems Biology Approach to Study Metabolic Syndrome. Springer International Publishing, 2014. pp. 27-61
@inbook{adc2ee589fb44d899f055676a30c6218,
title = "The liver in metabolic syndrome",
abstract = "The liver plays a major role in the regulation of pathways that govern systemic metabolic homeostasis. Hepatic regulation of glucose and lipid homeostasis is under the control of a complex system of hormones, transcription factors, and signaling pathways. Hepatic steatosis is a condition characterized by an increased amount of fat in the liver, mainly in the form of triglycerides, in a quantity greater than 5{\%} of liver weight, or histologically defined when 5{\%} or more of hepatocytes contains visible intracellular triglycerides, that cannot be attributed to alcohol consumption. Fatty liver is closely related to impairment in glucose, fatty acid, and lipoprotein metabolism, and it is now widely recognized as the hepatic manifestation of the Metabolic Syndrome. In the present chapter we will critically present the potential mechanisms that link obesity, type 2 diabetes, hepatic lipid accumulation, and insulin resistance. Indeed, although the correlation between fatty liver and insulin resistance is well established, we will specifically discuss the combination of elevated serum levels of glucose, fatty acids, and peripheral insulin resistance for the pathogenesis of liver dysfunction in the Metabolic Syndrome.",
keywords = "Insulin resistance, Lipid metabolism, Metabolic syndrome, Nonalcoholic fatty liver disease, Nonalcoholic steatohepatitis",
author = "Simona D’amore and Giuseppe Palasciano and Antonio Moschetta",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-3-319-01008-3_3",
language = "English (US)",
isbn = "9783319010083",
pages = "27--61",
booktitle = "A Systems Biology Approach to Study Metabolic Syndrome",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - The liver in metabolic syndrome

AU - D’amore, Simona

AU - Palasciano, Giuseppe

AU - Moschetta, Antonio

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The liver plays a major role in the regulation of pathways that govern systemic metabolic homeostasis. Hepatic regulation of glucose and lipid homeostasis is under the control of a complex system of hormones, transcription factors, and signaling pathways. Hepatic steatosis is a condition characterized by an increased amount of fat in the liver, mainly in the form of triglycerides, in a quantity greater than 5% of liver weight, or histologically defined when 5% or more of hepatocytes contains visible intracellular triglycerides, that cannot be attributed to alcohol consumption. Fatty liver is closely related to impairment in glucose, fatty acid, and lipoprotein metabolism, and it is now widely recognized as the hepatic manifestation of the Metabolic Syndrome. In the present chapter we will critically present the potential mechanisms that link obesity, type 2 diabetes, hepatic lipid accumulation, and insulin resistance. Indeed, although the correlation between fatty liver and insulin resistance is well established, we will specifically discuss the combination of elevated serum levels of glucose, fatty acids, and peripheral insulin resistance for the pathogenesis of liver dysfunction in the Metabolic Syndrome.

AB - The liver plays a major role in the regulation of pathways that govern systemic metabolic homeostasis. Hepatic regulation of glucose and lipid homeostasis is under the control of a complex system of hormones, transcription factors, and signaling pathways. Hepatic steatosis is a condition characterized by an increased amount of fat in the liver, mainly in the form of triglycerides, in a quantity greater than 5% of liver weight, or histologically defined when 5% or more of hepatocytes contains visible intracellular triglycerides, that cannot be attributed to alcohol consumption. Fatty liver is closely related to impairment in glucose, fatty acid, and lipoprotein metabolism, and it is now widely recognized as the hepatic manifestation of the Metabolic Syndrome. In the present chapter we will critically present the potential mechanisms that link obesity, type 2 diabetes, hepatic lipid accumulation, and insulin resistance. Indeed, although the correlation between fatty liver and insulin resistance is well established, we will specifically discuss the combination of elevated serum levels of glucose, fatty acids, and peripheral insulin resistance for the pathogenesis of liver dysfunction in the Metabolic Syndrome.

KW - Insulin resistance

KW - Lipid metabolism

KW - Metabolic syndrome

KW - Nonalcoholic fatty liver disease

KW - Nonalcoholic steatohepatitis

UR - http://www.scopus.com/inward/record.url?scp=84955733200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955733200&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-01008-3_3

DO - 10.1007/978-3-319-01008-3_3

M3 - Chapter

AN - SCOPUS:84955733200

SN - 9783319010083

SN - 9783319010076

SP - 27

EP - 61

BT - A Systems Biology Approach to Study Metabolic Syndrome

PB - Springer International Publishing

ER -