Liver X receptors (LXRs) are sterol-responsive transcription factors that regulates expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has imnplicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)