The liver X receptor gene team: Potential new players in atherosclerosis

Research output: Contribution to journalReview article

316 Scopus citations


Liver X receptors (LXRs) are sterol-responsive transcription factors that regulates expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has imnplicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.

Original languageEnglish (US)
Pages (from-to)1243-1248
Number of pages6
JournalNature medicine
Issue number11
StatePublished - Nov 1 2002


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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