TY - JOUR
T1 - The longevity gender gap
T2 - are telomeres the explanation?
AU - Aviv, Abraham
AU - Shay, Jerry
AU - Christensen, Karre
AU - Wright, Woodring
PY - 2005/6/8
Y1 - 2005/6/8
N2 - In this Perspective, we focus on the greater longevity of women as compared with men. We propose that, like aging itself, the longevity gender gap is exceedingly complex and argue that it may arise from sex-related hormonal differences and from somatic cell selection that favors cells more resistant to the ravages of time. We discuss the interplay of these factors with telomere biology and oxidative stress and suggest that an explanation for the longevity gender gap may arise from a better understanding of the differences in telomere dynamics between men and women.
AB - In this Perspective, we focus on the greater longevity of women as compared with men. We propose that, like aging itself, the longevity gender gap is exceedingly complex and argue that it may arise from sex-related hormonal differences and from somatic cell selection that favors cells more resistant to the ravages of time. We discuss the interplay of these factors with telomere biology and oxidative stress and suggest that an explanation for the longevity gender gap may arise from a better understanding of the differences in telomere dynamics between men and women.
UR - http://www.scopus.com/inward/record.url?scp=33644874920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644874920&partnerID=8YFLogxK
U2 - 10.1126/sageke.2005.23.pe16
DO - 10.1126/sageke.2005.23.pe16
M3 - Review article
C2 - 15944464
AN - SCOPUS:33644874920
SN - 1539-6150
VL - 2005
SP - pe16
JO - Science of aging knowledge environment : SAGE KE
JF - Science of aging knowledge environment : SAGE KE
IS - 23
ER -