The low-density lipoprotein receptor-related protein: Double agent or decoy?

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

The low-density lipoprotein receptor-related protein, a large cell-surface molecule with a multidomain structure, apparently serves a dual function, acting as a clearance receptor for two ligands that undergo activation during circulation in plasma. Chylomicron remnants (activated by apolipoprotein E enrichment) and α2-macroglobulin (activated by serum proteases) both bind avidly to this novel molecule.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalCurrent Opinion in Lipidology
Volume2
Issue number2
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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