The low-density lipoprotein receptor-related protein: Double agent or decoy?

Michael S. Brown; Joachim Herz; Robert C. Kowal; Joseph L. Goldstein

doi:10.1097/00041433-199104000-00002

The low-density lipoprotein receptor-related protein: Double agent or decoy?

Michael S. Brown, Joachim Herz, Robert C. Kowal, Joseph L. Goldstein

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Abstract

The low-density lipoprotein receptor-related protein, a large cell-surface molecule with a multidomain structure, apparently serves a dual function, acting as a clearance receptor for two ligands that undergo activation during circulation in plasma. Chylomicron remnants (activated by apolipoprotein E enrichment) and α₂-macroglobulin (activated by serum proteases) both bind avidly to this novel molecule.

Original language	English (US)
Pages (from-to)	65-72
Number of pages	8
Journal	Current opinion in lipidology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1097/00041433-199104000-00002
State	Published - 1991

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Molecular Biology
Genetics
Nutrition and Dietetics
Cardiology and Cardiovascular Medicine
Cell Biology

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10.1097/00041433-199104000-00002

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title = "The low-density lipoprotein receptor-related protein: Double agent or decoy?",

abstract = "The low-density lipoprotein receptor-related protein, a large cell-surface molecule with a multidomain structure, apparently serves a dual function, acting as a clearance receptor for two ligands that undergo activation during circulation in plasma. Chylomicron remnants (activated by apolipoprotein E enrichment) and α2-macroglobulin (activated by serum proteases) both bind avidly to this novel molecule.",

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AB - The low-density lipoprotein receptor-related protein, a large cell-surface molecule with a multidomain structure, apparently serves a dual function, acting as a clearance receptor for two ligands that undergo activation during circulation in plasma. Chylomicron remnants (activated by apolipoprotein E enrichment) and α2-macroglobulin (activated by serum proteases) both bind avidly to this novel molecule.

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The low-density lipoprotein receptor-related protein: Double agent or decoy?

Abstract

ASJC Scopus subject areas

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