The low-density lipoprotein receptor-related protein

Double agent or decoy?

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The low-density lipoprotein receptor-related protein, a large cell-surface molecule with a multidomain structure, apparently serves a dual function, acting as a clearance receptor for two ligands that undergo activation during circulation in plasma. Chylomicron remnants (activated by apolipoprotein E enrichment) and α2-macroglobulin (activated by serum proteases) both bind avidly to this novel molecule.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalCurrent Opinion in Lipidology
Volume2
Issue number2
StatePublished - 1991

Fingerprint

Chylomicron Remnants
LDL-Receptor Related Proteins
Apolipoprotein E2
Macroglobulins
LDL Receptors
Peptide Hydrolases
Ligands
Molecules
Serum
Proteins
Chemical activation
Plasmas

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The low-density lipoprotein receptor-related protein : Double agent or decoy? / Brown, Michael S.; Herz, Joachim; Kowal, Robert C.; Goldstein, Joseph L.

In: Current Opinion in Lipidology, Vol. 2, No. 2, 1991, p. 65-72.

Research output: Contribution to journalArticle

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