The LXRs: A new class of oxysterol receptors

Daniel J. Peet, Bethany A. Janowski, David J. Mangelsdorf

Research output: Contribution to journalArticle

291 Scopus citations

Abstract

The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping understand the function of these receptors in vivo and first suggested their role in the regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of LXR-deficient mice, which has demonstrated the essential function of one of these receptors in the liver as a major sensor of dietary cholesterol.

Original languageEnglish (US)
Pages (from-to)571-575
Number of pages5
JournalCurrent Opinion in Genetics and Development
Volume8
Issue number5
DOIs
Publication statusPublished - Oct 1998

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ASJC Scopus subject areas

  • Genetics

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