The MAGE protein family and cancer

Jenny L. Weon, Patrick Ryan Potts

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The Melanoma Antigen Gene (MAGE) protein family is a large, highly conserved group of proteins that share a common MAGE homology domain. Intriguingly, many MAGE proteins are restricted in expression to reproductive tissues, but are aberrantly expressed in a wide variety of cancer types. Originally discovered as antigens on tumor cells and developed as cancer immunotherapy targets, recent literature suggests a more prominent role for MAGEs in driving tumorigenesis. This review will highlight recent developments into the function of MAGEs as oncogenes, their mechanisms of action in regulation of ubiquitin ligases, and outstanding questions in the field.

Original languageEnglish (US)
Article number1370
Pages (from-to)1-8
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume37
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Cell Biology

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