TY - JOUR
T1 - The MAGE protein family and cancer
AU - Weon, Jenny L.
AU - Potts, Patrick Ryan
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - The Melanoma Antigen Gene (MAGE) protein family is a large, highly conserved group of proteins that share a common MAGE homology domain. Intriguingly, many MAGE proteins are restricted in expression to reproductive tissues, but are aberrantly expressed in a wide variety of cancer types. Originally discovered as antigens on tumor cells and developed as cancer immunotherapy targets, recent literature suggests a more prominent role for MAGEs in driving tumorigenesis. This review will highlight recent developments into the function of MAGEs as oncogenes, their mechanisms of action in regulation of ubiquitin ligases, and outstanding questions in the field.
AB - The Melanoma Antigen Gene (MAGE) protein family is a large, highly conserved group of proteins that share a common MAGE homology domain. Intriguingly, many MAGE proteins are restricted in expression to reproductive tissues, but are aberrantly expressed in a wide variety of cancer types. Originally discovered as antigens on tumor cells and developed as cancer immunotherapy targets, recent literature suggests a more prominent role for MAGEs in driving tumorigenesis. This review will highlight recent developments into the function of MAGEs as oncogenes, their mechanisms of action in regulation of ubiquitin ligases, and outstanding questions in the field.
UR - http://www.scopus.com/inward/record.url?scp=84940732703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940732703&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2015.08.002
DO - 10.1016/j.ceb.2015.08.002
M3 - Review article
C2 - 26342994
AN - SCOPUS:84940732703
SN - 0955-0674
VL - 37
SP - 1
EP - 8
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -