The MAGE protein family and cancer

Jenny L. Weon, Patrick Ryan Potts

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The Melanoma Antigen Gene (MAGE) protein family is a large, highly conserved group of proteins that share a common MAGE homology domain. Intriguingly, many MAGE proteins are restricted in expression to reproductive tissues, but are aberrantly expressed in a wide variety of cancer types. Originally discovered as antigens on tumor cells and developed as cancer immunotherapy targets, recent literature suggests a more prominent role for MAGEs in driving tumorigenesis. This review will highlight recent developments into the function of MAGEs as oncogenes, their mechanisms of action in regulation of ubiquitin ligases, and outstanding questions in the field.

Original languageEnglish (US)
Article number1370
Pages (from-to)1-8
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume37
DOIs
StatePublished - Dec 1 2015

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Melanoma-Specific Antigens
Neoplasms
Proteins
Neoplasm Antigens
Ligases
Ubiquitin
Oncogenes
Immunotherapy
Carcinogenesis
Genes

ASJC Scopus subject areas

  • Cell Biology

Cite this

The MAGE protein family and cancer. / Weon, Jenny L.; Potts, Patrick Ryan.

In: Current Opinion in Cell Biology, Vol. 37, 1370, 01.12.2015, p. 1-8.

Research output: Contribution to journalArticle

Weon, Jenny L. ; Potts, Patrick Ryan. / The MAGE protein family and cancer. In: Current Opinion in Cell Biology. 2015 ; Vol. 37. pp. 1-8.
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