TY - JOUR
T1 - The malaria parasite has an intrinsic clock
AU - Rijo-Ferreira, Filipa
AU - Acosta-Rodriguez, Victoria A.
AU - Abel, John H.
AU - Kornblum, Izabela
AU - Bento, Ines
AU - Kilaru, Gokhul
AU - Klerman, Elizabeth B.
AU - Mota, Maria M.
AU - Takahashi, Joseph S.
N1 - Funding Information:
We thank K. Matthews and M. Phillips for helpful discussions; N. Garduño and G. Martinez for assistance in maintaining mice in the automated feeders and performing smears; M. deGroot for breeding the Fbxl3 mutant mice; and L. Thomas for breeding both Fbxl3 mutant and Cry1/Cry2 double-knockout mice. We also thank K. Slavic, S. Marques, V. Zuzarte-Luis, Â. F. Chora, and I. M. Vera for help during WTLD collection. Thanks also to K. Cox for editing the manuscript, F. Augusto for the artwork, and both for helping us communicate these findings clearly. The authors acknowledge the Texas Advanced Computing Center (TACC) at the University of Texas at Austin for providing HPC resources that have contributed to the research results reported within this paper (www.tacc.utexas.edu) and the BioHPC cluster at UTSW. Funding: F.R.-F. is an Associate, I.K. is a Lab Manager II, and J.S.T. is an Investigator n the Howard Hughes Medical Institute. J.H.A. is supported by NIH NIA F32-AG064886 and NIH T32-HLO9701; E.B.K. by NIH R01-HL128538, K24-HL105664, and P01-AG009975 and the MGH Department of Neurology; and M.M.M. by PTDC/BIA-MOL/ 30112/2017 and PTDC/MED-IMU/28664/2017. M.M.M. is supported by FCT grants (PTDC/BIA-MOL/30112/2017 and - 2 2 -
Publisher Copyright:
Copyright © 2020 The Authors,
PY - 2020/5/15
Y1 - 2020/5/15
N2 - Malarial rhythmic fevers are the consequence of the synchronous bursting of red blood cells (RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that an intrinsic clock in the parasite Plasmodium chabaudi underlies the 24-hour-based rhythms of RBC bursting in mice. We show that parasite rhythms are flexible and lengthen to match the rhythms of hosts with long circadian periods. We also show that malaria rhythms persist even when host food intake is evenly spread across 24 hours, suggesting that host feeding cues are not required for synchrony. Moreover, we find that the parasite population remains synchronous and rhythmic even in an arrhythmic clock mutant host. Thus, we propose that parasite rhythms are generated by the parasite, possibly to anticipate its circadian environment.
AB - Malarial rhythmic fevers are the consequence of the synchronous bursting of red blood cells (RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that an intrinsic clock in the parasite Plasmodium chabaudi underlies the 24-hour-based rhythms of RBC bursting in mice. We show that parasite rhythms are flexible and lengthen to match the rhythms of hosts with long circadian periods. We also show that malaria rhythms persist even when host food intake is evenly spread across 24 hours, suggesting that host feeding cues are not required for synchrony. Moreover, we find that the parasite population remains synchronous and rhythmic even in an arrhythmic clock mutant host. Thus, we propose that parasite rhythms are generated by the parasite, possibly to anticipate its circadian environment.
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U2 - 10.1126/science.aba2658
DO - 10.1126/science.aba2658
M3 - Article
C2 - 32409471
AN - SCOPUS:85085158427
SN - 0036-8075
VL - 368
SP - 746
EP - 753
JO - Science
JF - Science
IS - 6492
ER -