The mammalian Mediator complex

Joan Weliky Conaway, Laurence Florens, Shigeo Sato, Chieri Tomomori-Sato, Tari J. Parmely, Tingting Yao, Selene K. Swanson, Charles A.S. Banks, Michael P. Washburn, Ronald C. Conaway

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.

Original languageEnglish (US)
Pages (from-to)904-908
Number of pages5
JournalFEBS Letters
Volume579
Issue number4 SPEC. ISS.
DOIs
StatePublished - Feb 7 2005
Externally publishedYes

Keywords

  • Mass spectrometry
  • Mediator
  • Messenger RNA synthesis
  • MudPIT
  • RNA polymerase II
  • Transcription factor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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