The mammalian Mediator complex and its role in transcriptional regulation

Ronald C. Conaway; Shigeo Sato; Chieri Tomomori-Sato; Tingting Yao; Joan W. Conaway

doi:10.1016/j.tibs.2005.03.002

The mammalian Mediator complex and its role in transcriptional regulation

Ronald C. Conaway, Shigeo Sato, Chieri Tomomori-Sato, Tingting Yao, Joan W. Conaway

Research output: Contribution to journal › Review article › peer-review

237 Scopus citations

Abstract

Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.

Original language	English (US)
Pages (from-to)	250-255
Number of pages	6
Journal	Trends in biochemical sciences
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/j.tibs.2005.03.002
State	Published - May 2005
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2005.03.002

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abstract = "Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.",

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note = "Funding Information: Work in the authors' laboratory is supported, in part, by National Institutes of Health Grant R37 GM41628.",

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AU - Yao, Tingting

AU - Conaway, Joan W.

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AB - Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.

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The mammalian Mediator complex and its role in transcriptional regulation

Abstract

ASJC Scopus subject areas

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