The management of acute bone loss in severe catabolism due to burn injury

G. L. Klein, S. E. Wolf, W. G. Goodman, W. A. Phillips, D. N. Herndon

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Reduced bone formation has been documented in both children and adults following burn injury of ≤ 40% total body surface area. In children, reduced bone formation and hypercalciuria may be the underlying causes of acute and sustained reduction in bone mineral density. The possible consequences of this reduction are an increase in extrapolated annual fracture incidence and reduced peak bone mass. Excessive endogenous glucocorticoid production, immobilization, bone marrow suppression, and magnesium depletion are all postulated as underlying causes. The most promising potential management agent is recombinant human growth hormone, which can stimulate bone formation via production of insulin-like growth factor I(IGF-I) and its associated binding protein, IGFBP-3, which correlates with bone mineral density in adults. Long-term treatment may be necessary to see a positive effect on bone formation and bone density. Correcting any detected magnesium depletion, and exercise as tolerated, are two other management strategies that might improve bone formation in this population.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalHormone Research
Volume48
Issue numberSUPPL. 5
StatePublished - Nov 1997

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Osteogenesis
Bone and Bones
Bone Density
Wounds and Injuries
Magnesium
Hypercalciuria
Insulin-Like Growth Factor Binding Protein 3
Human Growth Hormone
Body Surface Area
Insulin-Like Growth Factor I
Immobilization
Glucocorticoids
Growth Hormone
Carrier Proteins
Bone Marrow
Exercise
Incidence
Population
Therapeutics

Keywords

  • Bone density
  • Bone formation
  • Bone resorption
  • Burns
  • Cytokines
  • Glucocorticoids
  • Growth hormone
  • Immobilization

ASJC Scopus subject areas

  • Endocrinology

Cite this

Klein, G. L., Wolf, S. E., Goodman, W. G., Phillips, W. A., & Herndon, D. N. (1997). The management of acute bone loss in severe catabolism due to burn injury. Hormone Research, 48(SUPPL. 5), 83-87.

The management of acute bone loss in severe catabolism due to burn injury. / Klein, G. L.; Wolf, S. E.; Goodman, W. G.; Phillips, W. A.; Herndon, D. N.

In: Hormone Research, Vol. 48, No. SUPPL. 5, 11.1997, p. 83-87.

Research output: Contribution to journalArticle

Klein, GL, Wolf, SE, Goodman, WG, Phillips, WA & Herndon, DN 1997, 'The management of acute bone loss in severe catabolism due to burn injury', Hormone Research, vol. 48, no. SUPPL. 5, pp. 83-87.
Klein GL, Wolf SE, Goodman WG, Phillips WA, Herndon DN. The management of acute bone loss in severe catabolism due to burn injury. Hormone Research. 1997 Nov;48(SUPPL. 5):83-87.
Klein, G. L. ; Wolf, S. E. ; Goodman, W. G. ; Phillips, W. A. ; Herndon, D. N. / The management of acute bone loss in severe catabolism due to burn injury. In: Hormone Research. 1997 ; Vol. 48, No. SUPPL. 5. pp. 83-87.
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