Abstract
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 32-42 |
| Number of pages | 11 |
| Journal | Nature Reviews Genetics |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2009 |
Fingerprint
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
- Molecular Biology
Cite this
The many roles of histone deacetylases in development and physiology : Implications for disease and therapy. / Haberland, Michael; Montgomery, Rusty L.; Olson, Eric N.
In: Nature Reviews Genetics, Vol. 10, No. 1, 01.2009, p. 32-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The many roles of histone deacetylases in development and physiology
T2 - Implications for disease and therapy
AU - Haberland, Michael
AU - Montgomery, Rusty L.
AU - Olson, Eric N.
PY - 2009/1
Y1 - 2009/1
N2 - Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.
AB - Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.
UR - http://www.scopus.com/inward/record.url?scp=57749170458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57749170458&partnerID=8YFLogxK
U2 - 10.1038/nrg2485
DO - 10.1038/nrg2485
M3 - Article
C2 - 19065135
AN - SCOPUS:57749170458
VL - 10
SP - 32
EP - 42
JO - Nature reviews. Genetics
JF - Nature reviews. Genetics
SN - 1471-0056
IS - 1
ER -