TY - JOUR
T1 - The many roles of histone deacetylases in development and physiology
T2 - Implications for disease and therapy
AU - Haberland, Michael
AU - Montgomery, Rusty L.
AU - Olson, Eric N.
N1 - Funding Information:
We apologize to the many authors in the field whose work we were not able to cite because of space constraints. Research in the Olson laboratory has been supported by grants from the National Institutes of Health, the D.W. Reynolds Clinical Cardiovascular Research Center, the Robert A. Welch Foundation and the Sandler Foundation for Asthma Research. M.H was supported by a grant from the Deutsche Forschungsgemeinschaft (DFG, HA 3335/2-1).
PY - 2009/1
Y1 - 2009/1
N2 - Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.
AB - Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.
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U2 - 10.1038/nrg2485
DO - 10.1038/nrg2485
M3 - Review article
C2 - 19065135
AN - SCOPUS:57749170458
VL - 10
SP - 32
EP - 42
JO - Nature reviews. Genetics
JF - Nature reviews. Genetics
SN - 1471-0056
IS - 1
ER -