The many roles of histone deacetylases in development and physiology: Implications for disease and therapy

Michael Haberland, Rusty L. Montgomery, Eric N. Olson

Research output: Contribution to journalReview article

1532 Scopus citations

Abstract

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.

Original languageEnglish (US)
Pages (from-to)32-42
Number of pages11
JournalNature Reviews Genetics
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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