TY - JOUR
T1 - The mechanism of action of glatiramer acetate treatment in multiple sclerosis
AU - Racke, Michael K.
AU - Lovett-Racke, Amy E.
AU - Karandikar, Nitin J.
PY - 2010/1
Y1 - 2010/1
N2 - Objective: Glatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple sclerosis. Its mechanism of action over the past 40 years has evolved with our understanding of the immune response. Methods: We review the various mechanisms that have been proposed for this random polymer over the years, with emphasis on recent methods that utilize modern immunologic techniques. Results: Studies describing processes such as immune deviation and effects on regulatory T cells and antigen-presenting cells are presented. Conclusions: Effects of glatiramer acetate on the immune response have evolved as our technical abilities and knowledge of the immune response itself have developed.
AB - Objective: Glatiramer acetate (formerly known as copolymer 1) is the major noninterferon immunomodulatory agent used in the treatment of relapsing-remitting multiple sclerosis. Its mechanism of action over the past 40 years has evolved with our understanding of the immune response. Methods: We review the various mechanisms that have been proposed for this random polymer over the years, with emphasis on recent methods that utilize modern immunologic techniques. Results: Studies describing processes such as immune deviation and effects on regulatory T cells and antigen-presenting cells are presented. Conclusions: Effects of glatiramer acetate on the immune response have evolved as our technical abilities and knowledge of the immune response itself have developed.
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U2 - 10.1212/WNL.0b013e3181c97e39
DO - 10.1212/WNL.0b013e3181c97e39
M3 - Article
C2 - 20038760
AN - SCOPUS:74249111385
SN - 0028-3878
VL - 74
SP - S25-S30
JO - Neurology
JF - Neurology
IS - 1 SUPPL.
ER -