The mechanism of receptor-mediated endocytosis: More questions than answers

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Receptor-mediated endocytosis occurs via clathrin-coated pits and is therefore coupled to the dynamic cycle of assembly and disassembly of the coat constituents. These coat proteins comprise part, but certainly not all, of the machinery involved in the recognition of membrane receptors and their selective packaging into transport vesicles for internalization. Despite considerable knowledge about the biochemistry of coated vesicles and purified coat proteins, little is known about the mechanisms of coated pit assembly, receptor-sorting and coated vesicle formation. Cell-free assays which faithfully reconstitute these events provide powerful new tools with which to elucidate the overall mechanism of receptor-mediated endocytosis.

Original languageEnglish (US)
Pages (from-to)589-596
Number of pages8
JournalBioEssays
Volume14
Issue number9
StatePublished - 1992

Fingerprint

Coated Vesicles
Capsid Proteins
endocytosis
Endocytosis
coated vesicles
Transport Vesicles
Clathrin
receptors
Biochemistry
Product Packaging
coat proteins
Sorting
Machinery
Assays
Packaging
Membranes
clathrin
biochemistry
sorting
packaging

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

The mechanism of receptor-mediated endocytosis : More questions than answers. / Schmid, Sandra L.

In: BioEssays, Vol. 14, No. 9, 1992, p. 589-596.

Research output: Contribution to journalArticle

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