The mechanism of receptor‐mediated endocytosis: More questions than answers

Sandra L. Schmid

Research output: Contribution to journalReview article

84 Scopus citations

Abstract

Receptor‐mediated endocytosis occurs via clathrin‐coated pits and is therefore coupled to the dynamic cycle of assembly and disassembly of the coat constituents. These coat proteins comprise part, but certainly not all, of the machinery involved in the recognition of membrane receptors and their selective packaging into transport vesicles for internalization. Despite considerable knowledge about the biochemistry of coated vesicles and purified coat proteins, little is known about the mechanisms of coated pit assembly, receptor‐sorting and coated vesicle formation. Cell‐free assays which faithfully reconstitute these events provide powerful new tools with which to elucidate the overall mechanism of receptor‐mediated endocytosis.

Original languageEnglish (US)
Pages (from-to)589-596
Number of pages8
JournalBioEssays
Volume14
Issue number9
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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