The mechanism of the urinary concentrating defect in potassium deficient rats

Felix P. Brunner, Floyd C. Rector, Donald W. Seldin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The mechanism of the defect in urinary concentrating capacity in potassium deficiency was investigated by measuring solute-free water reabsorption ( {Mathematical expression}) in normal and hypokalemic rats undergoing mannitol diuresis. Since potassium-deficiency markedly lowered glomerular filtration rate (GFR), {Mathematical expression} was examined in normal rats whose GFR had been comparably reduced either acutely by aortic constriction or chronically by feeding a salt- and protein-free diet. By calculating the volume of filtrate delivered to the loop of Henle from the GFR and Cosmit was found that in normal rats {Mathematical expression} was linearly related to volume delivery. At each level of volume delivery to the loop hypokalemic rats formed about half the normal amount of {Mathematical expression}. Decreased solute delivery to the loop of Henle, therefore, cannot be the cause of the concentrating defect in hypokalemia. It is concluded, therefore, that the impaired concentrating capacity in potassium deficiency results from defective sodium transport in the ascending limb of Henle's loop, so that at any level of sodium delivery to the loop less sodium is transported into the medulla and therefore less {Mathematical expression} is generated.

Original languageEnglish (US)
Pages (from-to)202-210
Number of pages9
JournalPflügers Archiv für die Gesamte Physiologie des Menschen und der Tiere
Volume290
Issue number3
DOIs
StatePublished - Sep 1966

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Potassium Deficiency
Loop of Henle
Rats
Potassium
Glomerular Filtration Rate
Defects
Sodium
Sodium-Restricted Diet
Protein-Restricted Diet
Hypokalemia
Diuresis
Mannitol
Nutrition
Constriction
Salts
Water
Proteins

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)

Cite this

The mechanism of the urinary concentrating defect in potassium deficient rats. / Brunner, Felix P.; Rector, Floyd C.; Seldin, Donald W.

In: Pflügers Archiv für die Gesamte Physiologie des Menschen und der Tiere, Vol. 290, No. 3, 09.1966, p. 202-210.

Research output: Contribution to journalArticle

Brunner, Felix P. ; Rector, Floyd C. ; Seldin, Donald W. / The mechanism of the urinary concentrating defect in potassium deficient rats. In: Pflügers Archiv für die Gesamte Physiologie des Menschen und der Tiere. 1966 ; Vol. 290, No. 3. pp. 202-210.
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