Anaphylactic shock decreased the coronary perfusion pressure, systemic arterial pressure and cardiac output in anesthetised dogs. After combined inhibition of cyclo-oxygenase and lipoxygenase with linoleate-hydroxamic acid, the anaphylactic coronary constriction and morphological cardiac lesions were considerably diminished. Activation of the lipoxygenase pathway seems to play a major role in development of the coronary constriction in anaphylaxis.
|Translated title of the contribution||The mechanisms of the changes in coronary vascular resistance in anaphylactic shock|
|Number of pages||6|
|Journal||Fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk|
|State||Published - Feb 1 1994|
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