Abstract
Anaphylactic shock decreased the coronary perfusion pressure, systemic arterial pressure and cardiac output in anesthetised dogs. After combined inhibition of cyclo-oxygenase and lipoxygenase with linoleate-hydroxamic acid, the anaphylactic coronary constriction and morphological cardiac lesions were considerably diminished. Activation of the lipoxygenase pathway seems to play a major role in development of the coronary constriction in anaphylaxis.
Translated title of the contribution | The mechanisms of the changes in coronary vascular resistance in anaphylactic shock |
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Original language | Russian |
Pages (from-to) | 77-82 |
Number of pages | 6 |
Journal | Fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk |
Volume | 80 |
Issue number | 2 |
State | Published - Feb 1 1994 |
ASJC Scopus subject areas
- Physiology