The mechanosensitive ion channel traak is localized to the mammalian node of ranvier

Stephen G. Brohawn, Weiwei Wang, Annie Handler, Ernest B. Campbell, Jürgen R. Schwarz, Roderick MacKinnon

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


TRAAK is a membrane tension-activated K+ channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice to show that TRAAK is localized exclusively to nodes of Ranvier, the action potential propagating elements of myelinated nerve fibers. Approximately 80 percent of myelinated nerve fibers throughout the central and peripheral nervous system contain TRAAK in what is likely an all-nodes or no-nodes per axon fashion. TRAAK is not observed at the axon initial segment where action potentials are first generated. We used polyclonal antibodies, the TRAAK inhibitor RU2 and node clamp amplifiers to demonstrate the presence and functional properties of TRAAK in rat nerve fibers. TRAAK contributes to the ‘leak’ K+ current in mammalian nerve fiber conduction by hyperpolarizing the resting membrane potential, thereby increasing Na+ channel availability for action potential propagation. We speculate on why nodes of Ranvier contain a mechanosensitive K+ channel.

Original languageEnglish (US)
Article numbere50403
StatePublished - Nov 2019
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'The mechanosensitive ion channel traak is localized to the mammalian node of ranvier'. Together they form a unique fingerprint.

Cite this